PDF(Pubmed)
Abstract：
Equine melanomas are a common neoplasm in gray horses. However, scientific knowledge about their progression over time is quite scarce. Some owners and veterinarians still believe that early intervention is not necessary, stating that tumors evolve very slowly and intervention could worsen the animal\'s condition. This work aims to identify clinical and histological differences that may exist between equine melanomas with different excision intervals (time between tumor detection and surgical excision). A total of 42 tumors (13 benign and 29 malignant) from 34 horses were included in this study. There was a statistically significant association between excision interval and tumor size (p = 0.038), with tumors excised later being significantly larger than the ones excised sooner. The excision interval was also statistically associated with the number of tumors (p = 0.011), since the horses that carried a tumor for longer seemed to be prone to have multiple tumors. Furthermore, there was an association between excision interval and malignancy (p = 0.035), with tumor excised later being fives times more likely to be malignant. This study provides evidence of delayed excision\'s effect on the progression of equine melanomas. Additionally, it reinforces the importance of the early excision of these tumors.
摘要：
马黑色素瘤是灰马的常见肿瘤。然而,关于它们随时间发展的科学知识相当缺乏。一些业主和兽医仍然认为，早期干预是没有必要的，指出肿瘤进化非常缓慢，干预可能会使动物的病情恶化。这项工作旨在确定不同切除间隔（肿瘤检测和手术切除之间的时间）的马黑色素瘤之间可能存在的临床和组织学差异。本研究包括来自34匹马的总共42个肿瘤(13个良性和29个恶性)。切除间隔与肿瘤大小之间存在统计学上的显着关联（p=0.038），切除后的肿瘤明显大于切除后的肿瘤。切除间隔也与肿瘤数量有统计学关联（p=0.011），因为携带肿瘤时间更长的马似乎容易患有多种肿瘤。此外，切除间隔与恶性肿瘤之间存在关联（p=0.035），后来切除的肿瘤是恶性的可能性的五倍。这项研究提供了延迟切除对马黑色素瘤进展的影响的证据。此外,它加强了早期切除这些肿瘤的重要性。
