PDF(Pubmed)
Abstract：
(1) Background. Diabetes mellitus (DM), called the first non-infectious epidemic of the modern era, has long-term health consequences leading to a reduced quality of life, long-term disabilities, and high mortality. Diabetic retinopathy (DR) is a neurovascular complication of diabetes and accounts for about 80% cases of vision loss in the diabetic population. The adaptive optics (AO) technique allows for a non-invasive in vivo assessment of retinal cones. Changes in number or morphology of retinal cones may be one of the first indicators of DR. (2) Methods. This study included 68 DM1 patients (17 women) aged 42.11 ± 9.69 years with a mean duration of diabetes of 22.07 ± 10.28 years, and 41 healthy volunteers (20 women) aged 41.02 ± 9.84 years. Blood pressure, BMI, waist circumference, and metabolic control measures were analysed. Cones\' morphological parameters were examined with a retinal camera with Imagine Eyes adaptive optics (rtx1). Statistical analysis was carried out with IMB SPSS version 23 software. (3) Results. Neither study group differed significantly in age, BMI, blood pressure, or eyeball length. Intraocular pressure (IOP) was statistically significantly higher in DM1 patients but remained within physiological range in both groups. Analysis of cone parameters showed a statistically significant lower mean regularity of cones (Rmean) in the DM1 group compared to control group (p = 0.01), with the lowest value in the group with DM1 and hypertension (p = 0.014). In addition, DM1 patients tended to have fewer cones. (4) Conclusions. Our study revealed abnormalities in cone and vessel parameters and these abnormalities should be considered as risk factors for the development of DR. Complementing an eye examination with AO facilitates non-invasive in vivo cellular imaging of the retina. Lesions like those detected in the eye may occur in the brain and certainly require further investigation.
摘要：
（1）背景。糖尿病(DM),被称为现代第一次非传染性流行病，有长期的健康后果，导致生活质量下降，长期残疾,和高死亡率。糖尿病视网膜病变（DR）是糖尿病的神经血管并发症，约占糖尿病人群视力丧失的80％。自适应光学（AO）技术允许对视网膜视锥进行非侵入性体内评估。视网膜视锥的数量或形态变化可能是DR的首要指标之一。（2）方法。这项研究包括68名DM1患者（17名女性），年龄为42.11±9.69岁，平均糖尿病持续时间为22.07±10.28年，41名健康志愿者(20名女性)，年龄41.02±9.84岁。血压,BMI,腰围,和代谢控制措施进行了分析。使用具有ImagineEyes自适应光学器件（rtx1）的视网膜相机检查了视锥形态参数。用IMBSPSS版本23软件进行统计学分析。（3）结果。两个研究组在年龄上都没有显着差异，BMI,血压,或眼球长度。DM1患者的眼压（IOP）在统计学上显着较高，但两组均保持在生理范围内。视锥参数分析显示，与对照组相比，DM1组的视锥平均规律性（Rmean）在统计学上显着降低（p=0.01），在DM1和高血压组中，该值最低(p=0.014)。此外,DM1患者倾向于有较少的视锥细胞。（4）结论。我们的研究显示锥体和血管参数异常，这些异常应被视为发展DR的危险因素。用AO补充眼睛检查有助于视网膜的非侵入性体内细胞成像。像在眼睛中检测到的病变可能发生在大脑中，当然需要进一步调查。
