PDF(Pubmed)
Abstract：
Ischemic stroke poses a significant global health challenge, necessitating ongoing exploration of its pathophysiology and treatment strategies. This comprehensive review integrates various aspects of ischemic stroke research, emphasizing crucial mechanisms, therapeutic approaches, and the role of clinical imaging in disease management. It discusses the multifaceted role of Netrin-1, highlighting its potential in promoting neurovascular repair and mitigating post-stroke neurological decline. It also examines the impact of blood-brain barrier permeability on stroke outcomes and explores alternative therapeutic targets such as statins and sphingosine-1-phosphate signaling. Neurocardiology investigations underscore the contribution of cardiac factors to post-stroke mortality, emphasizing the importance of understanding the brain-heart axis for targeted interventions. Additionally, the review advocates for early reperfusion and neuroprotective agents to counter-time-dependent excitotoxicity and inflammation, aiming to preserve tissue viability. Advanced imaging techniques, including DWI, PI, and MR angiography, are discussed for their role in evaluating ischemic penumbra evolution and guiding therapeutic decisions. By integrating molecular insights with imaging modalities, this interdisciplinary approach enhances our understanding of ischemic stroke and offers promising avenues for future research and clinical interventions to improve patient outcomes.
摘要：
缺血性卒中构成了重大的全球健康挑战，需要不断探索其病理生理学和治疗策略。这篇综合综述整合了缺血性卒中研究的各个方面，强调关键机制，治疗方法，以及临床影像学在疾病管理中的作用。它讨论了Netrin-1的多方面作用，强调了其在促进神经血管修复和减轻中风后神经系统衰退方面的潜力。它还研究了血脑屏障通透性对中风结果的影响，并探索了他汀类药物和鞘氨醇-1-磷酸信号传导等替代治疗靶点。神经心脏病学研究强调了心脏因素对卒中后死亡率的影响，强调了解脑-心轴对于有针对性的干预的重要性。此外,该综述提倡早期再灌注和神经保护剂对抗时间依赖性兴奋性毒性和炎症，旨在保持组织活力。先进的成像技术，包括DWI,PI,和MR血管造影,讨论了它们在评估缺血半暗带演变和指导治疗决策中的作用。通过将分子见解与成像模式相结合，这种跨学科方法增强了我们对缺血性卒中的理解,并为未来研究和临床干预提供了有希望的途径,以改善患者预后.
