PDF(Pubmed)
Abstract：
Myocardial ischemia-reperfusion injury (MIRI) remains a challenge in the context of reperfusion procedures for myocardial infarction (MI). While early revascularization stands as the gold standard for mitigating myocardial injury, recent insights have illuminated the paradoxical role of reperfusion, giving rise to the phenomenon known as ischemia-reperfusion injury. This comprehensive review delves into the intricate pathophysiological pathways involved in MIRI, placing a particular focus on the pivotal role of endothelium. Beyond elucidating the molecular intricacies, we explore the diverse clinical manifestations associated with MIRI, underscoring its potential to contribute substantially to the final infarct size, up to 50%. We further navigate through current preventive approaches and highlight promising emerging strategies designed to counteract the devastating effects of the phenomenon. By synthesizing current knowledge and offering a perspective on evolving preventive interventions, this review serves as a valuable resource for clinicians and researchers engaged in the dynamic field of MIRI.
摘要：
心肌缺血再灌注损伤（MIRI）在心肌梗死（MI）的再灌注程序中仍然是一个挑战。早期血运重建是减轻心肌损伤的金标准,最近的见解阐明了再灌注的矛盾作用，引起称为缺血再灌注损伤的现象。这篇全面的综述深入探讨了MIRI涉及的复杂的病理生理途径，特别关注内皮的关键作用。除了阐明分子的复杂性，我们探讨了与MIRI相关的各种临床表现，强调其对最终梗死面积有实质性贡献的潜力，高达50%。我们进一步浏览当前的预防方法，并强调旨在抵消这一现象的破坏性影响的有希望的新兴战略。通过综合现有知识并提供对不断发展的预防性干预措施的观点，这篇综述为从事MIRI动态领域的临床医生和研究人员提供了宝贵的资源。
