PDF(Pubmed)
Abstract：
Fibromyalgia is a chronic, widespread pain disorder that is strongly represented across the affective and cognitive dimensions of pain, given that the underlying pathophysiology of the disorder is yet to be identified. These affective and cognitive deficits are crucial to understanding and treating the fibromyalgia pain experience as a whole but replicating this multidimensionality on a preclinical level is challenging. To understand the underlying mechanisms, animal models are used. In this scoping review, we evaluate the current primary animal models of fibromyalgia regarding their translational relevance within the affective and cognitive pain realms, as well as summarize treatments that have been identified preclinically for attenuating these deficits.
摘要：
纤维肌痛是一种慢性,广泛的疼痛障碍，在疼痛的情感和认知维度上有很强的代表性，鉴于该疾病的潜在病理生理学尚未确定。这些情感和认知缺陷对于整体理解和治疗纤维肌痛疼痛体验至关重要，但在临床前水平上复制这种多维性具有挑战性。要了解潜在的机制，使用动物模型。在这次范围审查中，我们评估了目前纤维肌痛的主要动物模型，关于它们在情感和认知疼痛领域的翻译相关性，以及总结临床前已确定用于减轻这些缺陷的治疗方法。
