PDF(Pubmed)
Abstract：
BACKGROUND: Antiretroviral therapy has allowed a clear improvement in prognosis for HIV patients, but metabolic problems, such as dyslipidemia, remain. This can lead to the development of atheromatous plaques. Our study aims to evaluate whether HIV-positive (HIV+) patients show higher myo-intimal media thickness (IMT) and atheromatous plaques compared to HIV-negative (HIV-) patients.
METHODS: To evaluate the association between HIV infection in experienced patients and vascular pathology, we performed a cross-sectional study, observing 1006 patients, 380 HIV+ enrolled in the Archiprevaleat cohort, and 626 HIV- as a control group. All patients underwent a Doppler scan of the supra-aortic vessels. We compared the prevalence of IMT > 1.0 mm and plaques in the two groups.
RESULTS: Patients in the HIV+ group were younger than those in the HIV- group, with a lower prevalence of hypertension and diabetes and higher dyslipidemia. The prevalence of plaques in strata of age was higher in the HIV+ group than in the HIV- group and was associated with the length of ART exposure.
CONCLUSIONS: Our cross-sectional, retrospective study shows that HIV+ experienced patients are at greater risk of IMT and atheromatous plaques compared to HIV-. The risk is associated with being HIV+ and with the length of ART exposure. This finding may be useful in preventing cardiovascular risk.
METHODS: To evaluate the association between HIV infection in experienced patients and vascular pathology, we performed a cross-sectional study, observing 1006 patients, 380 HIV+ enrolled in the Archiprevaleat cohort, and 626 HIV- as a control group. All patients underwent a Doppler scan of the supra-aortic vessels. We compared the prevalence of IMT > 1.0 mm and plaques in the two groups.
RESULTS: Patients in the HIV+ group were younger than those in the HIV- group, with a lower prevalence of hypertension and diabetes and higher dyslipidemia. The prevalence of plaques in strata of age was higher in the HIV+ group than in the HIV- group and was associated with the length of ART exposure.
CONCLUSIONS: Our cross-sectional, retrospective study shows that HIV+ experienced patients are at greater risk of IMT and atheromatous plaques compared to HIV-. The risk is associated with being HIV+ and with the length of ART exposure. This finding may be useful in preventing cardiovascular risk.
摘要：
背景：抗逆转录病毒治疗使HIV患者的预后得到明显改善，但是代谢问题，如血脂异常，remain.这可能导致动脉粥样斑块的发展。我们的研究旨在评估与HIV阴性（HIV-）患者相比，HIV阳性（HIV）患者是否显示出更高的内膜中层厚度（IMT）和动脉粥样斑块。
方法：为了评估有经验患者的HIV感染与血管病理学之间的关系，我们进行了横断面研究,观察1006名患者，380名HIV+在Archiprevaleat队列中注册，和626HIV-作为对照组。所有患者均接受了主动脉上血管的多普勒扫描。我们比较了两组中IMT>1.0mm和斑块的患病率。
结果：HIV+组患者比HIV-组患者年轻，高血压和糖尿病患病率较低，血脂异常较高。年龄层次中的斑块患病率在HIV+组中高于HIV-组，并且与ART暴露时间有关。
结论：我们的横截面，回顾性研究显示,与HIV-患者相比,HIV+患者发生IMT和粥样斑块的风险更高.该风险与HIV+和ART暴露时间有关。这一发现可能有助于预防心血管风险。
方法：为了评估有经验患者的HIV感染与血管病理学之间的关系，我们进行了横断面研究,观察1006名患者，380名HIV+在Archiprevaleat队列中注册，和626HIV-作为对照组。所有患者均接受了主动脉上血管的多普勒扫描。我们比较了两组中IMT>1.0mm和斑块的患病率。
结果：HIV+组患者比HIV-组患者年轻，高血压和糖尿病患病率较低，血脂异常较高。年龄层次中的斑块患病率在HIV+组中高于HIV-组，并且与ART暴露时间有关。
结论：我们的横截面，回顾性研究显示,与HIV-患者相比,HIV+患者发生IMT和粥样斑块的风险更高.该风险与HIV+和ART暴露时间有关。这一发现可能有助于预防心血管风险。
