PDF(Pubmed)
Abstract：
The human gastrointestinal tract houses a diverse range of microbial species that play an integral part in many biological functions. Several preclinical studies using germ-free mice models have demonstrated that the gut microbiome profoundly influences carcinogenesis and progression. Colorectal cancer appears to be associated with microbial dysbiosis involving certain bacterial species, including F. nucleatum, pks+ E. coli, and B. fragilis, with virome commensals also disrupted in patients. A dysbiosis toward these pro-carcinogenic species increases significantly in CRC patients, with reduced numbers of the preventative species Clostridium butyicum, Roseburia, and Bifidobacterium evident. There is also a correlation between Clostridium infection and CRC. F. nucleatum, in particular, is strongly associated with CRC where it is associated with therapeutic resistance and poor outcomes in patients. The carcinogenic mode of action of pathogenic bacteria in CRC is a result of genotoxicity, epigenetic alterations, ROS generation, and pro-inflammatory activity. The aim of this review is to discuss the microbial species and their impact on colorectal cancer in terms of disease initiation, progression, and metastasis. The potential of anticancer peptides as anticancer agents or adjuvants is also discussed, as novel treatment options are required to combat the high levels of resistance to current pharmaceutical options.
摘要：
人的胃肠道容纳了各种各样的微生物物种，这些物种在许多生物学功能中起着不可或缺的作用。一些使用无菌小鼠模型的临床前研究表明，肠道微生物组深刻地影响癌的发生和进展。大肠癌似乎与涉及某些细菌物种的微生物菌群失调有关，包括F.核仁,PKS+大肠杆菌，还有B.fragilis,与病毒共生也中断了患者。CRC患者对这些致癌物种的生态失调显着增加，随着预防物种丁酸梭菌数量的减少，罗斯布里亚,和双歧杆菌明显。梭菌感染与CRC之间也存在相关性。F.核仁，特别是,与CRC密切相关,CRC与患者的治疗耐药和不良预后相关。CRC中病原菌的致癌作用模式是遗传毒性的结果，表观遗传改变，ROS生成，和促炎活性。这篇综述的目的是讨论微生物种类及其在疾病发生方面对结直肠癌的影响。programming,和转移。还讨论了抗癌肽作为抗癌剂或佐剂的潜力，因为需要新的治疗方案来对抗对当前药物选择的高水平耐药性。
