PDF(Pubmed)
Abstract：
(1) Background: Intervertebral disc degeneration has been linked to obesity; its potential mechanical effects on the intervertebral disc remain unknown. This study aimed to develop and validate a patient-specific model of L3-L4 vertebrae and then use the model to estimate the impact of increasing body weight on disc degeneration. (2) Methods: A three-dimensional model of the functional spinal unit of L3-L4 vertebrae and its components were developed and validated. Validation was achieved by comparing the range of motions (RoM) and intradiscal pressures with the previous literature. Subsequently, the validated model was loaded according to the body mass index and estimated stress, deformation, and RoM to assess disc degeneration. (3) Results: During validation, L3-L4 RoM and intradiscal pressures: flexion 5.17° and 1.04 MPa, extension 1.54° and 0.22 MPa, lateral bending 3.36° and 0.54 MPa, axial rotation 1.14° and 0.52 MPa, respectively. When investigating the impact of weight on disc degeneration, escalating from normal weight to obesity reveals an increased RoM, by 3.44% during flexion, 22.7% during extension, 29.71% during lateral bending, and 33.2% during axial rotation, respectively. Also, stress and disc deformation elevated with increasing weight across all RoM. (4) Conclusions: The predicted mechanical responses of the developed model closely matched the validation dataset. The validated model predicts disc degeneration under increased weight and could lay the foundation for future recommendations aimed at identifying predictors of lower back pain due to disc degeneration.
摘要：
（1）背景：椎间盘退变与肥胖有关；其对椎间盘的潜在机械作用尚不清楚。本研究旨在开发和验证L3-L4椎骨的患者特异性模型，然后使用该模型来评估体重增加对椎间盘退变的影响。(2)方法:建立了L3-L4椎体的脊柱功能单元及其组成部分的三维模型,并进行了验证。通过将运动范围（RoM）和椎间盘内压力与以前的文献进行比较来实现验证。随后，根据体重指数和估计的应力加载经过验证的模型，变形,和RoM评估椎间盘退变。(3)结果：在验证期间，L3-L4RoM和椎间盘内压力：屈曲5.17°和1.04MPa，延伸1.54°和0.22MPa，横向弯曲3.36°和0.54MPa，轴向旋转1.14°和0.52MPa，分别。在研究体重对椎间盘退变的影响时，从正常体重到肥胖的升级揭示了RoM的增加，屈曲时的3.44%，延长期间的22.7%，侧向弯曲时29.71%，轴向旋转时的33.2%，分别。此外，应力和圆盘变形随着所有RoM重量的增加而升高。（4）结论：所开发模型的预测力学响应与验证数据集紧密匹配。经过验证的模型可以预测体重增加时的椎间盘退变，并为将来旨在确定由于椎间盘退变引起的下背痛的预测因子的建议奠定了基础。
