PDF(Pubmed)
Abstract：
Magnetic robots possess an innate ability to navigate through hard-to-reach cavities in the human body, making them promising tools for diagnosing and treating diseases minimally invasively. Despite significant advances, the development of robots with desirable locomotion and full biocompatibility under harsh physiological conditions remains challenging, which put forward new requirements for magnetic robots\' design and material synthesis. Compared to robots that are synthesized with inorganic materials, natural organisms like cells, bacteria or other microalgae exhibit ideal properties for in vivo applications, such as biocompatibility, deformability, auto-fluorescence, and self-propulsion, as well as easy for functional therapeutics engineering. In the process, these organisms can provide autonomous propulsion in biological fluids or external magnetic fields, while retaining their functionalities with integrating artificial robots, thus aiding targeted therapeutic delivery. This kind of robotics is named bio-hybrid magnetic robotics, and in this mini-review, recent progress including their design, engineering and potential for therapeutics delivery will be discussed. Additionally, the historical context and prominent examples will be introduced, and the complexities, potential pitfalls, and opportunities associated with bio-hybrid magnetic robotics will be discussed.
摘要：
磁性机器人具有在人体难以到达的空腔中导航的先天能力，使它们成为微创诊断和治疗疾病的有前途的工具。尽管取得了重大进展，在恶劣的生理条件下开发具有理想运动能力和完全生物相容性的机器人仍然具有挑战性，这对磁性机器人的设计和材料合成提出了新的要求。与用无机材料合成的机器人相比，像细胞这样的天然生物，细菌或其他微藻表现出理想的体内应用特性，如生物相容性，可变形性,自动荧光，和自我推进，以及易于进行功能治疗工程。在这个过程中,这些生物可以在生物流体或外部磁场中提供自主推进，同时通过集成人工机器人来保留它们的功能，从而帮助靶向治疗递送。这种机器人被称为生物混合磁机器人，在这个小型审查中，最近的进展，包括他们的设计，工程和治疗递送的潜力将被讨论。此外,将介绍历史背景和突出的例子，和复杂性，潜在的陷阱，将讨论与生物混合磁性机器人技术相关的机会。
