PDF(Pubmed)
Abstract：
This article reviews the avian viruses that infect the skin of domestic farm birds of primary economic importance: chicken, duck, turkey, and goose. Many avian viruses (e.g., poxviruses, herpesviruses, Influenza viruses, retroviruses) leading to pathologies infect the skin and the appendages of these birds. Some of these viruses (e.g., Marek\'s disease virus, avian influenza viruses) have had and/or still have a devasting impact on the poultry economy. The skin tropism of these viruses is key to the pathology and virus life cycle, in particular for virus entry, shedding, and/or transmission. In addition, for some emergent arboviruses, such as flaviviruses, the skin is often the entry gate of the virus after mosquito bites, whether or not the host develops symptoms (e.g., West Nile virus). Various avian skin models, from primary cells to three-dimensional models, are currently available to better understand virus-skin interactions (such as replication, pathogenesis, cell response, and co-infection). These models may be key to finding solutions to prevent or halt viral infection in poultry.
摘要：
本文回顾了感染主要经济重要性的家养农场鸟类皮肤的禽类病毒：鸡，鸭子,土耳其,和鹅。许多禽类病毒(例如，痘病毒,疱疹病毒,流感病毒,逆转录病毒）导致病理感染这些鸟类的皮肤和附属物。其中一些病毒(例如，马立克病病毒,禽流感病毒）已经和/或仍然对家禽经济产生破坏性影响。这些病毒的皮肤嗜性是病理学和病毒生命周期的关键，特别是对于病毒进入，脱落，和/或传输。此外,对于一些新兴的虫媒病毒，如黄病毒，蚊虫叮咬后，皮肤往往是病毒的入口，宿主是否出现症状(例如，西尼罗河病毒）。各种鸟类皮肤模型，从原代细胞到三维模型，目前可以更好地了解病毒与皮肤的相互作用(如复制，发病机制，细胞反应，和共感染)。这些模型可能是找到预防或阻止家禽病毒感染的解决方案的关键。
