Abstract：
The skeletal muscle is well known for its remarkable ability to regenerate after injuries. The regeneration is a complex and dynamic process that involves muscle stem cells (also called muscle satellite cells, MuSCs), fibro-adipogenic progenitors (FAPs), immune cells, and other muscle-resident cell populations. The MuSCs are the myogenic cell populaiton that contribute nuclei directly to the regenerated myofibers, while the other cell types collaboratively establish a microenvironment that facilitates myogenesis of MuSCs. The myogenic process includes activation, proliferation and differentiationof MuSCs, and subsequent fusion their descendent mononuclear myocytes into multinuclear myotubes. While the contributions of FAPs and immune cells to this microenvironment have been well studied, the influence of MuSCs on other cell types remains poorly understood. This review explores recent evidence supporting the potential role of MuSCs as immunomodulators during muscle regeneration, either through cytokine production or ligand-receptor interactions.
摘要：
众所周知，骨骼肌在受伤后具有非凡的再生能力。再生是一个复杂而动态的过程，涉及肌肉干细胞（也称为肌肉卫星细胞，MuSC),纤维脂肪原祖细胞（FAP），免疫细胞，和其他肌肉驻留细胞群。MuSCs是直接向再生肌纤维贡献细胞核的肌原细胞群，而其他细胞类型协作建立促进MuSCs成肌的微环境。肌源性过程包括激活，MuSCs的增殖和分化，随后将其后代的单核肌细胞融合为多核肌管。虽然FAP和免疫细胞对这种微环境的贡献已经得到了很好的研究，MuSCs对其他细胞类型的影响尚不清楚。这篇综述探讨了支持MuSCs在肌肉再生过程中作为免疫调节剂的潜在作用的最新证据。通过细胞因子产生或配体-受体相互作用。
