Abstract：
BACKGROUND: The leaves of Nelumbo nucifera Gaertn. Are recorded in the earliest written documentation of traditional Chinese medicinal as \"Ben Cao Gang Mu\", a medicinal herb for blood clotting, dysentery and dizziness. Nuciferine, one of N. nucifera Gaertn. leaf extracts, has been shown to possess several pharmacological properties, including but not limited to ameliorating hyperlipidemia, stimulating insulin secretion, inducing vasodilation, reducing blood pressure, and demonstrating anti-arrhythmic properties.
OBJECTIVE: In light of the latest research findings on nuciferine, this article provides a comprehensive overview of its chemical properties, pharmacological activities, and the underlying regulatory mechanisms. It aims to serve as a dependable reference for further investigations into the pharmacological effects and mechanisms of nuciferine.
METHODS: Use Google Scholar, Scifinder, PubMed, Springer, Elsevier, Wiley, Web of Science and other online database search to collect the literature on extraction, separation, structural analysis and pharmacological activity of nuciferine published before November 2023. The key words are \"extraction\", \"isolation\", \"purification\" and \"pharmacological action\" and \"nuciferine\".
RESULTS: Nuciferine has been widely used in the treatment of ameliorating hyperlipidemia and lose weight, Nuciferine is a monomeric aporphine alkaloid extracted from the leaves of the plant Nymphaea caerulea and Nelumbo nucifera Gaertn. Nuciferine has pharmacological activities such as relaxing smooth muscles, improving hyperlipidemia, stimulating insulin secretion, vasodilation, inducing hypotension, antiarrhythmic effects, and antimicrobial and anti-HIV activities. These pharmacological properties lay a foundation for the treatment of tumors, inflammation, hyperglycemia, lipid-lowering and weight-loss, oxidative stress and other diseases with nuciferine.
CONCLUSIONS: Nuciferine has been clinically used to treat hyperlipidemia and aid in weight loss due to its effects on lipid levels, insulin secretion, vasodilation, blood pressure reduction, anti-tumor properties, and immune enhancement. However, other potential benefits of nuciferine have not yet been fully explored in clinical practice. Future research should delve deeper into its molecular structure, toxicity, side effects, and clinical pharmacology to uncover its full range of effects and pave the way for its safe and expanded clinical use.
OBJECTIVE: In light of the latest research findings on nuciferine, this article provides a comprehensive overview of its chemical properties, pharmacological activities, and the underlying regulatory mechanisms. It aims to serve as a dependable reference for further investigations into the pharmacological effects and mechanisms of nuciferine.
METHODS: Use Google Scholar, Scifinder, PubMed, Springer, Elsevier, Wiley, Web of Science and other online database search to collect the literature on extraction, separation, structural analysis and pharmacological activity of nuciferine published before November 2023. The key words are \"extraction\", \"isolation\", \"purification\" and \"pharmacological action\" and \"nuciferine\".
RESULTS: Nuciferine has been widely used in the treatment of ameliorating hyperlipidemia and lose weight, Nuciferine is a monomeric aporphine alkaloid extracted from the leaves of the plant Nymphaea caerulea and Nelumbo nucifera Gaertn. Nuciferine has pharmacological activities such as relaxing smooth muscles, improving hyperlipidemia, stimulating insulin secretion, vasodilation, inducing hypotension, antiarrhythmic effects, and antimicrobial and anti-HIV activities. These pharmacological properties lay a foundation for the treatment of tumors, inflammation, hyperglycemia, lipid-lowering and weight-loss, oxidative stress and other diseases with nuciferine.
CONCLUSIONS: Nuciferine has been clinically used to treat hyperlipidemia and aid in weight loss due to its effects on lipid levels, insulin secretion, vasodilation, blood pressure reduction, anti-tumor properties, and immune enhancement. However, other potential benefits of nuciferine have not yet been fully explored in clinical practice. Future research should delve deeper into its molecular structure, toxicity, side effects, and clinical pharmacology to uncover its full range of effects and pave the way for its safe and expanded clinical use.
摘要：
背景：NelumbonuciferaGaertn的叶子。在最早的中医书面文献中记载为“本草岗目”，一种治疗血液凝固的药草，痢疾和头晕。荷叶碱,一个N.nuciferaGaertn.叶提取物,已被证明具有几种药理特性，包括但不限于改善高脂血症，刺激胰岛素分泌，诱导血管舒张，降低血压,并证明了抗心律失常的特性。
目的：根据最新的研究发现，本文对其化学性质进行了全面的概述，药理活性，以及潜在的监管机制。它的目的是作为进一步研究荷叶碱的药理作用和机制的可靠参考。
方法：使用谷歌学者，Scifinder,PubMed,Springer,Elsevier,威利,WebofScience和其他在线数据库搜索，以收集提取的文献，分离,2023年11月之前发表的荷叶碱的结构分析和药理活性。关键词是\"提取\",\"隔离\",“纯化”和“药理作用”和“荷叶碱”。
结果：荷叶碱已广泛用于治疗高脂血症和减轻体重，Nuciferine是从植物Nymphaeacaerulea和NelumbonuciferaGaertn的叶子中提取的单体阿帕芬生物碱。荷叶碱具有药理活性，如放松平滑肌，改善高脂血症，刺激胰岛素分泌，血管舒张,诱导低血压，抗心律失常作用，以及抗菌和抗HIV活性。这些药理特性为肿瘤的治疗奠定了基础,炎症,高血糖症,降脂和减肥，氧化应激和其他疾病。
结论：由于其对血脂水平的影响，Nucificine已在临床上用于治疗高脂血症和帮助体重减轻，胰岛素分泌，血管舒张,血压降低,抗肿瘤特性，和免疫增强。然而,在临床实践中尚未充分探索荷叶碱的其他潜在益处。未来的研究应该更深入地研究它的分子结构，毒性,副作用,和临床药理学，以揭示其全方位的作用，并为其安全和扩大临床使用铺平道路。
目的：根据最新的研究发现，本文对其化学性质进行了全面的概述，药理活性，以及潜在的监管机制。它的目的是作为进一步研究荷叶碱的药理作用和机制的可靠参考。
方法：使用谷歌学者，Scifinder,PubMed,Springer,Elsevier,威利,WebofScience和其他在线数据库搜索，以收集提取的文献，分离,2023年11月之前发表的荷叶碱的结构分析和药理活性。关键词是\"提取\",\"隔离\",“纯化”和“药理作用”和“荷叶碱”。
结果：荷叶碱已广泛用于治疗高脂血症和减轻体重，Nuciferine是从植物Nymphaeacaerulea和NelumbonuciferaGaertn的叶子中提取的单体阿帕芬生物碱。荷叶碱具有药理活性，如放松平滑肌，改善高脂血症，刺激胰岛素分泌，血管舒张,诱导低血压，抗心律失常作用，以及抗菌和抗HIV活性。这些药理特性为肿瘤的治疗奠定了基础,炎症,高血糖症,降脂和减肥，氧化应激和其他疾病。
结论：由于其对血脂水平的影响，Nucificine已在临床上用于治疗高脂血症和帮助体重减轻，胰岛素分泌，血管舒张,血压降低,抗肿瘤特性，和免疫增强。然而,在临床实践中尚未充分探索荷叶碱的其他潜在益处。未来的研究应该更深入地研究它的分子结构，毒性,副作用,和临床药理学，以揭示其全方位的作用，并为其安全和扩大临床使用铺平道路。
