捕获 IL - 6 并增强 CAR - T 细胞抗肿瘤反应的嵌合细胞因子受体的开发。
关键词: CAR-T IL-6 IL-7 JAK-STAT signaling adoptive immunotherapy chimeric antigen receptor cytokine release syndrome hematological malignancy neurotoxicity solid tumor
Mesh : Animals Humans Interleukin-6 / metabolism immunology Immunotherapy, Adoptive / methods Mice Receptors, Chimeric Antigen / immunology metabolism T-Lymphocytes / immunology metabolism Cell Line, Tumor Cytokine Receptor gp130 / metabolism Neoplasms / immunology therapy Xenograft Model Antitumor Assays Receptors, Cytokine / metabolism genetics Receptors, Interleukin-6 / metabolism Receptors, Interleukin-7 / metabolism
来 源:
DOI:10.1016/j.xcrm.2024.101526
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