Abstract：
Interleukin 15 (IL-15) has emerged as a crucial factor in the relationship between natural killer (NK) cells and immunotherapy for cancer. This review article aims to provide a comprehensive understanding of the role of IL-15 in NK cell-mediated immunotherapy. First, the key role of IL-15 signaling in NK cell immunity is discussed, highlighting its regulation of NK cell functions and antitumor properties. Furthermore, the use of IL-15 or its analogs in clinical trials as a therapeutic strategy for various cancers, including the genetic modification of NK cells to produce IL-15, has been explored. The potential of IL-15-based therapies, such as chimeric antigen receptor (CAR) T and NK cell infusion along with IL-15 in combination with checkpoint inhibitors and other treatments, has been examined. This review also addresses the challenges and advantages of incorporating IL-15 in cell-based immunotherapy. Additionally, unresolved questions regarding the detection and biological significance of the soluble IL-15/IL-15Rα complex, as well as the potential role of IL-15/IL-15Rα in human cancer and the immunological consequences of prolonged exposure to soluble IL-15 for NK cells, are discussed.
摘要：
白细胞介素15（IL-15）已成为自然杀伤（NK）细胞与癌症免疫治疗之间关系的关键因素。本文旨在全面了解IL-15在NK细胞介导的免疫治疗中的作用。首先,讨论了IL-15信号在NK细胞免疫中的关键作用，强调其对NK细胞功能和抗肿瘤特性的调节。此外，在临床试验中使用IL-15或其类似物作为各种癌症的治疗策略，包括对NK细胞进行遗传修饰以产生IL-15的研究。基于IL-15的治疗的潜力，例如嵌合抗原受体（CAR）T和NK细胞输注以及IL-15与检查点抑制剂和其他治疗相结合，已经检查过了。这篇综述还讨论了在基于细胞的免疫疗法中掺入IL-15的挑战和优势。此外,关于可溶性IL-15/IL-15Rα复合物的检测和生物学意义的悬而未决的问题，以及IL-15/IL-15Rα在人类癌症中的潜在作用以及长期暴露于可溶性IL-15对NK细胞的免疫学后果，正在讨论。
