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Abstract：
This study aimed to investigate the relationship between endoscopic gastroesophageal valve grading and mean nocturnal baseline impedance (MNBI) and postreflux swallow-induced peristaltic wave index (PSPWI) in patients with gastroesophageal reflux disease (GERD). A total of 120 patients diagnosed with GERD disease were included in the study. According to the classification of endoscopic gastroesophageal valves, the patients were divided into 5 groups, group 1 as baseline group, and Group 2-4 as Hill grade I-IV. Basic information about the patients was collected, including age and gender. The mean nocturnal baseline impedance and creep wave index induced by swallowing after rumination were measured by high resolution creep measurement technique. Through statistical analysis, the relationship between valve classification and observation index was discussed. In terms of MNBI, impedance values gradually decreased with increasing valve classification. The average impedance of the Grade 1 group was 23.5 mm Hg/cm2, while the average impedance of the Grade 5 group was 15.2 mm Hg/cm2. This reduction showed a significant decreasing trend (P < .001). In addition, in terms of the peristaltic wave index caused by swallowing after regurgitation, the peristaltic wave index gradually increased with the increase of valve classification. The mean index in the Grade 1 group was 1.8 beats/min, while the mean index in the Grade 5 group was 3.6 beats/min. This increase showed a significant positive relationship (P < .001). Endoscopic gastroesophageal valve grading was significantly correlated with MNBI and PSPWI in patients with GERD. These observations can serve as useful tools for assessing the severity of GERD and monitoring disease progression.
摘要：
本研究旨在探讨胃食管反流病（GERD）患者内镜下胃食管瓣膜分级与夜间平均基线阻抗（MNBI）及吞咽后蠕动波指数（PSPWI）的关系。总共120例诊断为GERD疾病的患者被纳入研究。根据内镜下胃食管瓣膜的分类，将患者分为5组，第1组为基线组，第2-4组是希尔I-IV级。收集患者的基本信息，包括年龄和性别。通过高分辨率蠕变测量技术测量了反冲后吞咽引起的平均夜间基线阻抗和蠕变波指数。通过统计分析,讨论了瓣膜分类与观察指标的关系。就MNBI而言,随着瓣膜分级的增加,阻抗值逐渐降低。1级组的平均阻抗为23.5mmHg/cm2,而5级组的平均阻抗为15.2mmHg/cm2。这种减少表现出显著的下降趋势(P<.001)。此外,在反流后吞咽引起的蠕动波指数方面，随着瓣膜分级的增加，蠕动波指数逐渐增加。1级组的平均指数为1.8次/分钟，而5级组的平均指数为3.6次/分。这种增加显示出显著的正相关(P<.001)。GERD患者内镜下胃食管瓣膜分级与MNBI和PSPWI显著相关。这些观察结果可作为评估GERD严重程度和监测疾病进展的有用工具。
