PDF(Pubmed)
Abstract：
Transcription factors (TFs) play a pivotal role as regulators of gene expression, orchestrating the formation and maintenance of diverse animal body plans and innovations. However, the precise contributions of TFs and the underlying mechanisms driving the origin of basal metazoan body plans, particularly in ctenophores, remain elusive. Here, we present a comprehensive catalog of TFs in 2 ctenophore species, Pleurobrachia bachei and Mnemiopsis leidyi, revealing 428 and 418 TFs in their respective genomes. In contrast, morphologically simpler metazoans have a reduced TF representation compared to ctenophores, cnidarians, and bilaterians: the sponge Amphimedon encodes 277 TFs, and the placozoan Trichoplax adhaerens encodes 274 TFs. The emergence of complex ctenophore tissues and organs coincides with significant lineage-specific diversification of the zinc finger C2H2 (ZF-C2H2) and homeobox superfamilies of TFs. Notable, the lineages leading to Amphimedon and Trichoplax exhibit independent expansions of leucine zipper (BZIP) TFs. Some lineage-specific TFs may have evolved through the domestication of mobile elements, thereby supporting alternative mechanisms of parallel TF evolution and body plan diversification across the Metazoa.
摘要：
转录因子(TFs)作为基因表达调控因子发挥着关键作用,协调各种动物身体计划和创新的形成和维护。然而,TFs的精确贡献和驱动基础后生动物身体计划起源的潜在机制，特别是在足月动物中，仍然难以捉摸。这里,我们提供了2种ctenophore物种中的TFs的综合目录，巴氏胸膜轻臂和莱伊米，在各自的基因组中揭示428和418个TFs。相比之下,形态上更简单的后生动物与尾状目相比具有减少的TF表现，CNIDarians,和双边：海绵Amphimedon编码277TFs，而胎盘Trichoplaxadhaerens编码274个TFs。复杂的ctenophore组织和器官的出现与锌指C2H2（ZF-C2H2）和TFs的同源异型盒超家族的明显谱系特异性多样化相吻合。值得注意的,导致Amphimedon和Trichoplax的谱系表现出亮氨酸拉链（BZIP）TF的独立扩展。一些特定于谱系的TF可能是通过对移动元素的驯化而进化而来的，从而支持跨Metazoa的并行TF进化和身体计划多样化的替代机制。
