Abstract：
Negative symptoms in CHR-P people are generally not responsive to treatments and commonly related to poorer functional outcome. However, less research attention has been dedicated to Persistent Negative Symptoms (PNS), defined as clinically stable negative symptoms of moderate severity evident for at least 6 months. This study aims to (a) determine the prevalence of PNS in a sample of young people at CHR-P; (b) investigate any association of PNS with functioning and clinical features; (c) examine longitudinal course of PNS across 2 years of follow-up and changes in PNS severity levels with specialized treatments. One Hundred Eighty CHR-P participants were recruited and were divided into CHR-P/PNS + and CHR-P/PNS- subgroups. The clinical assessments were based on the PANSS and the GAF and were conducted at baseline and every 12 months during the follow-up. Twenty four participants showed PNS at entry. Of them, 21 concluded the 2-year follow-up period. At baseline, the CHR-P/PNS + participants showed more educational and employment deficits, and more social and functioning impairment. During the follow-up, the CHR-P/PNS + subgroup had a significant longitudinal decrease in negative symptoms, which was specifically related to antidepressant treatment. CHR-P/PNS + subjects also showed a higher incidence of new hospitalization and a lower functional recovery over time. Our findings support that the persistence of negative symptoms in CHR-P people is longitudinally related to worse daily functioning and more severe clinical conditions that are at higher risk of hospitalization and are less responsive to specialized treatments.
摘要：
CHR-P人群的阴性症状通常对治疗无反应，并且通常与较差的功能结果有关。然而,较少研究关注持续阴性症状(PNS)，定义为临床稳定的阴性症状，中度严重程度明显至少6个月。这项研究旨在（a）确定CHR-P年轻人样本中PNS的患病率；（b）调查PNS与功能和临床特征的任何关联；（c）检查经过2年随访的PNS纵向病程以及采用专门治疗的PNS严重程度的变化。招募了180名CHR-P参与者，并将其分为CHR-P/PNS和CHR-P/PNS-亚组。临床评估基于PANSS和GAF，并在基线和随访期间每12个月进行一次。24名参与者在进入时显示PNS。其中,21结束了为期2年的随访期。在基线,CHR-P/PNS+参与者表现出更多的教育和就业赤字，以及更多的社会和功能损害。在后续行动中,CHR-P/PNS+亚组阴性症状纵向显著减少，这与抗抑郁治疗有关。随着时间的推移，CHR-P/PNS+受试者也显示出更高的新住院发生率和更低的功能恢复。我们的发现支持CHR-P人群中阴性症状的持续存在与更差的日常功能和更严重的临床状况纵向相关，这些疾病住院风险更高，对专门治疗的反应较差。
