PDF(Pubmed)
Abstract：
Pediatric sarcomas, rare malignancies of mesenchymal origin, pose diagnostic and therapeutic challenges. In this review, we explore the role of radiomics in reshaping our understanding of pediatric sarcomas, emphasizing methodological considerations and applications such as diagnostics and predictive modeling. A systematic review conducted up to November 2023 identified 72 papers on radiomics analysis in pediatric sarcoma from PubMed/MEDLINE, Web of Knowledge, and Scopus. Following inclusion and exclusion criteria, 10 reports were included in this review. The studies, predominantly retrospective, focus on Ewing sarcoma and osteosarcoma, utilizing diverse imaging modalities, including CT, MRI, PET/CT, and PET/MRI. Manual segmentation is common, with a median of 35 features extracted. Radiomics Quality Score (RQS) and Methodological Radiomics Score (METRICS) assessments reveal a consistent emphasis on non-radiomic features, validation criteria, and improved methodological rigor in recent publications. Diagnostic applications dominate, with innovative studies exploring prognostic and treatment response aspects. Challenges include feature heterogeneity and sample size variations. The evolving landscape underscores the need for standardized methodologies. Despite challenges, the diagnostic and predictive potential of radiomics in pediatric oncology is evident, paving the way for precision medicine advancements.
摘要：
小儿肉瘤,间充质起源的罕见恶性肿瘤，提出诊断和治疗挑战。在这次审查中,我们探讨了影像组学在重塑我们对小儿肉瘤的理解中的作用，强调方法论的考虑和应用，如诊断和预测建模。截至2023年11月进行的系统评价确定了来自PubMed/MEDLINE的72篇关于小儿肉瘤的影像组学分析的论文，WebofKnowledge,还有Scopus.按照纳入和排除标准，本次审查包括10份报告。研究,主要是回顾性的，重点关注尤因肉瘤和骨肉瘤，利用不同的成像方式，包括CT,MRI,PET/CT,PET/MRI。手动分割是常见的，提取了35个特征的中位数。影像组学质量评分（RQS）和方法论影像组学评分（METRICS）评估揭示了对非影像组学特征的一致强调，验证标准，并在最近的出版物中改进了方法上的严谨性。诊断应用程序占主导地位，探索预后和治疗反应方面的创新研究。挑战包括特征异质性和样本大小差异。不断变化的景观强调了标准化方法的必要性。尽管面临挑战,影像组学在儿科肿瘤学中的诊断和预测潜力是显而易见的，为精准医学的进步铺平了道路。
