PDF(Pubmed)
Abstract：
Recent studies have begun exploring the potential involvement of microbiota in the pathogenesis of oral lichen planus (OLP), yet comprehensive investigations remain limited. Hence, this study aimed to compare the microbial profiles in saliva samples obtained from patients with OLP against those from healthy controls (HC), along with a comparison between erosive (E) and non-erosive (NE) OLP patients. Saliva samples were collected from 60 OLP patients (E: n = 25, NE: n = 35) and 30 HC individuals. Analysis revealed no significant differences in alpha diversity, as assessed by the Chao1 and Shannon index, across the three groups. However, Bray-Curtis distance analysis indicated a significant disparity in microbiome composition distribution between HC and E-OLP, as well as HC and NE-OLP groups. The six most abundant phyla observed across the groups were Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Fusobacteria, and Saccharibacteria (TM7). Notably, OLP groups exhibited a higher prevalence of Bacteroidetes. Prevotella emerged as the predominant genus in the OLP groups, while Capnocytophaga showed a relatively higher prevalence in E-OLP compared to NE-OLP. This study\'s findings indicate a notable difference in microbiota composition between HC and patients with OLP. Additionally, differences in the microbiome were identified between the E-OLP and NE-OLP groups. The increase in the proportion of certain bacterial species in the oral microbiome suggests that they may exacerbate the inflammatory response and act as antigens for OLP.
摘要：
最近的研究已经开始探索微生物群在口腔扁平苔藓（OLP）发病机理中的潜在参与。然而，全面的调查仍然有限。因此，这项研究旨在比较从OLP患者获得的唾液样本中的微生物谱与健康对照（HC），以及糜烂性（E）和非糜烂性（NE）OLP患者之间的比较。从60名OLP患者(E:n=25,NE:n=35)和30名HC个体收集唾液样品。分析显示α多样性没有显著差异，根据Chao1和Shannon指数的评估，跨三组。然而,Bray-Curtis距离分析表明HC和E-OLP之间的微生物组组成分布存在显着差异，以及HC和NE-OLP组。在各组中观察到的六个最丰富的门是Firmicutes，拟杆菌,变形杆菌,放线菌,镰刀菌,和糖杆菌（TM7）。值得注意的是,OLP组表现出较高的拟杆菌患病率。Prevotella是OLP群体中的主要属，而Capnocytophaga在E-OLP中的患病率高于NE-OLP。这项研究的结果表明，HC和OLP患者之间的微生物组成存在显着差异。此外,在E-OLP组和NE-OLP组之间发现了微生物组的差异.口腔微生物组中某些细菌物种比例的增加表明它们可能加剧炎症反应并充当OLP的抗原。
