PDF(Pubmed)
Abstract：
Gynecological and obstetric infectious diseases are crucial to women\'s health. There is growing evidence that links the presence of Fusobacterium nucleatum (F. nucleatum), an anaerobic oral commensal and potential periodontal pathogen, to the development and progression of various human diseases, including cancers. While the role of this opportunistic oral pathogen has been extensively studied in colorectal cancer in recent years, research on its epidemiological evidence and mechanistic link to gynecological diseases (GDs) is still ongoing. Thus, the present review, which is the first of its kind, aims to undertake a comprehensive and critical reappraisal of F. nucleatum, including the genetics and mechanistic role in promoting adverse pregnancy outcomes (APOs) and various GDs, including cancers. Additionally, this review discusses new conceptual advances that link the immunomodulatory role of F. nucleatum to the development and progression of breast, ovarian, endometrial, and cervical carcinomas through the activation of various direct and indirect signaling pathways. However, further studies are needed to explore and elucidate the highly dynamic process of host-F. nucleatum interactions and discover new pathways, which will pave the way for the development of better preventive and therapeutic strategies against this pathobiont.
摘要：
妇科和产科传染病对妇女的健康至关重要。越来越多的证据表明核梭杆菌的存在(F.核仁)，厌氧性口腔共生和潜在的牙周病原体，各种人类疾病的发展和进展，包括癌症。虽然近年来已经广泛研究了这种机会性口腔病原体在结直肠癌中的作用，关于其流行病学证据和与妇科疾病（GD）的机制联系的研究仍在进行中。因此，本次审查,这是同类中的第一个，旨在对F.核仁进行全面而严格的重新评估，包括在促进不良妊娠结局（APO）和各种GD中的遗传学和机制作用，包括癌症。此外,这篇综述讨论了新的概念进展，这些进展将核仁F.的免疫调节作用与乳腺的发育和进展联系起来，卵巢,子宫内膜,和宫颈癌通过激活各种直接和间接信号通路。然而,需要进一步的研究来探索和阐明宿主F的高度动态过程。核仁相互作用并发现新的途径，这将为开发针对这种疾病的更好的预防和治疗策略铺平道路。
