PDF(Pubmed)
Abstract：
Microbial biofilm formation creates a persistent and resistant environment in which microorganisms can survive, contributing to antibiotic resistance and chronic inflammatory diseases. Increasingly, biofilms are caused by multi-drug resistant microorganisms, which, coupled with a diminishing supply of effective antibiotics, is driving the search for new antibiotic therapies. In this respect, antimicrobial peptides (AMPs) are short, hydrophobic, and amphipathic peptides that show activity against multidrug-resistant bacteria and biofilm formation. They also possess broad-spectrum activity and diverse mechanisms of action. In this comprehensive review, 150 publications (from January 2020 to September 2023) were collected and categorized using the search terms \'polypeptide antibiotic agent\', \'antimicrobial peptide\', and \'biofilm\'. During this period, a wide range of natural and synthetic AMPs were studied, of which LL-37, polymyxin B, GH12, and Nisin were the most frequently cited. Furthermore, although many microbes were studied, Staphylococcus aureus and Pseudomonas aeruginosa were the most popular. Publications also considered AMP combinations and the potential role of AMP delivery systems in increasing the efficacy of AMPs, including nanoparticle delivery. Relatively few publications focused on AMP resistance. This comprehensive review informs and guides researchers about the latest developments in AMP research, presenting promising evidence of the role of AMPs as effective antimicrobial agents.
摘要：
微生物生物膜的形成创造了一个持久和抵抗的环境，微生物可以在其中生存，导致抗生素耐药性和慢性炎症性疾病。越来越多,生物膜是由多重耐药微生物引起的，which,加上有效抗生素供应的减少，正在推动寻找新的抗生素疗法。在这方面,抗菌肽（AMP）短，疏水，和两亲性肽，显示出对抗多药耐药细菌和生物膜形成的活性。它们还具有广谱活性和多种作用机制。在这次全面审查中，收集了150份出版物(从2020年1月到2023年9月)，并使用搜索词“多肽抗生素剂”进行了分类，\'抗菌肽\',和“生物膜”。在此期间,研究了广泛的天然和合成AMP，其中LL-37，多粘菌素B，GH12和Nisin是最常被引用的。此外，尽管研究了许多微生物，金黄色葡萄球菌和铜绿假单胞菌最为流行。出版物还考虑了AMP组合以及AMP递送系统在增加AMP功效方面的潜在作用，包括纳米颗粒递送。关于AMP抗性的出版物相对较少。这份全面的综述告知和指导研究人员关于AMP研究的最新进展，提供了有希望的证据表明AMPs作为有效的抗微生物剂的作用。
