Meropenem-Vaborbactam for the Treatment of Post-Neurosurgical Meningitis Caused by KPC Producer Klebsiella Pneumoniae: A Case Report and Review of the Literature.

美罗培南 - 沃博巴坦用于治疗由 KPC 产生者肺炎克雷伯菌引起的神经外科术后脑膜炎 ： 病例报告并文献复习。

• 影响指数: 5.222
• 发表时间: 2024 Apr 5
• 来源期刊: Antibiotics (Basel)
• DOI: 10.3390/antibiotics13040331
• PMID: 38667007
• 文章类型: Case Reports
• 作者列表: Rezzonico LF,Peracchi F,Vecchi M,Bassi G,Merli M,Bana NB,Travi G,Crippa F,Puoti M

关键词: KPC; carbapenem-resistant Enterobacterales; central nervous system infection; meningitis; meropenem–vaborbactam

Abstract

Meningitis and ventriculitis, due to carbapenem-resistant Enterobacterales, are frequently associated with significant morbidity and mortality. In the case of multi-drug-resistant pathogens, it is necessary to consider the limited susceptibility profile as well as the penetration of the antimicrobials into the brain. Limited data are available regarding the treatment of central nervous system infections caused by carbapenem-resistant Enterobacterales. We report a study of a patient treated with meropenem-vaborbactam in the case of post-neurosurgical meningitis due to carbapenemase-producing Klebsiella pneumoniae (CPKP).

摘要

脑膜炎和脑室炎，由于耐碳青霉烯类肠杆菌，通常与显著的发病率和死亡率相关。在多重耐药病原体的情况下，有必要考虑有限的敏感性特征以及抗微生物剂对大脑的渗透。关于由耐碳青霉烯的肠杆菌引起的中枢神经系统感染的治疗，可用的数据有限。我们报告了一项研究，该研究是在由产生碳青霉烯酶的肺炎克雷伯菌（CPKP）引起的神经外科术后脑膜炎的情况下，接受美罗培南-vaborbactam治疗的患者。