PDF(Pubmed)
Abstract：
Despite ongoing research in the field of breast cancer, the morbidity rates indicate that the disease remains a significant challenge. While patients with primary tumors have relatively high survival rates, these chances significantly decrease once metastasis begins. Thus, exploring alternative approaches, such as targeting proteins overexpressed in malignancies, remains significant. Filamin A (FLNa), an actin-binding protein (ABP), is involved in various cellular processes, including cell migration, adhesion, proliferation, and DNA repair. Overexpression of the protein was confirmed in samples from patients with numerous oncological diseases such as prostate, lung, gastric, colorectal, and pancreatic cancer, as well as breast cancer. Although most researchers concur on its role in promoting breast cancer progression and aggressiveness, discrepancies exist among studies. Moreover, the precise mechanisms through which FLNa affects cell migration, invasion, and even cancer progression remain unclear, highlighting the need for further research. To evaluate FLNa\'s potential as a therapeutic target, we have summarized its roles in breast cancer.
摘要：
尽管在乳腺癌领域正在进行研究，发病率表明，这种疾病仍然是一个重大挑战。虽然原发性肿瘤患者的生存率相对较高，一旦转移开始，这些机会显着减少。因此，探索替代方法，例如靶向在恶性肿瘤中过表达的蛋白质，仍然很重要。丝状蛋白A(FLNa),肌动蛋白结合蛋白（ABP），参与各种细胞过程，包括细胞迁移，附着力,扩散,DNA修复在许多肿瘤疾病如前列腺患者的样本中证实了该蛋白的过表达。肺，胃,结直肠,和胰腺癌，以及乳腺癌。尽管大多数研究人员同意其在促进乳腺癌进展和侵袭性方面的作用，研究之间存在差异。此外，FLNa影响细胞迁移的确切机制，入侵,甚至癌症进展仍不清楚，强调需要进一步研究。为了评估FLNa作为治疗靶点的潜力，我们总结了它在乳腺癌中的作用。
