Abstract：
This retrospective cross-sectional study reviewed adult patients with operated cleft lip and/or palate (CL/P) and normal control, and performed comprehensive craniofacial and nasal morphological analyses based on lateral cephalometric radiographs. Pearson or Spearman correlation coefficient assessed intraclass correlation. Seven hundred fifty-seven operated patients with CL/P, and 165 noncleft normal controls were enrolled. Among the normal and CL/P groups, S-N-A angle registered positive correlations with nasal base prominence (S-N\'-Sn, degrees). Upper facial height (N-ANS, mm) had positive correlations with nasal dorsum length (N\'-Prn, mm) and nasal bone length (N-Na, mm). Although in patients with bilateral cleft lip and palate, there were moderate negative correlations ( r =-0.541, P <0.05) with soft tissue facial profile angle (FH-N\'Pog\', degree) and nasolabial angle (Cm-Sn-ULA, degree). Correlation exists between the morphology of jaw bones and external nose among patients with CL/P. Maxillary sagittal insufficiency is associated with concave nasal profile, and maxilla height is associated with nasal length.
摘要：
这项回顾性横断面研究回顾了成年唇裂和/或腭裂（CL/P）患者和正常对照，并根据侧位头颅X线片进行了全面的颅面和鼻形态学分析。皮尔逊或斯皮尔曼相关系数评估组内相关性。757名CL/P手术患者，纳入165名非裂隙正常对照。在正常组和CL/P组中，S-N-A角与鼻基底突出呈正相关(S-N'-Sn，度)。面部上部高度(N-ANS,mm）与鼻背长度呈正相关（N'-Prn，mm）和鼻骨长度（N-Na，mm).虽然在双侧唇腭裂患者中，与软组织面部轮廓角度呈中度负相关(r=-0.541，P<0.05)(FH-N\'Pog\'，度)和鼻唇沟角度(Cm-Sn-ULA，度)。CL/P患者颌骨形态与外鼻之间存在相关性。上颌矢状位功能不全与凹形鼻部轮廓有关，上颌骨高度与鼻长有关。
