Abstract：
UNASSIGNED: This study explores the relationship between acquired punctal stenosis (PS) and ocular surface disease (OSD), assessing causal mechanisms and clinical impacts, utilizing a combination of a comprehensive literature review and a detailed analysis of a patient cohort from a tertiary care center.
UNASSIGNED: Data from 213 PS patients at Sheba Medical Center were retrospectively analyzed, evaluating various OSD symptoms and treatment effectiveness through standardized clinical assessments and statistical tests.
UNASSIGNED: Predominantly older and female, many patients exhibited bilateral PS. OSD symptoms were found in 35.2% of all patients. Treatments like punctoplasty with stents significantly alleviated symptoms. Significant associations between treatment modalities and symptom improvement were identified.
UNASSIGNED: PS and OSD have acomplex, bidirectional relationship that complicates treatment outcomes. This study underscores the need for thorough diagnostic approaches and personalized treatments to improve PS management. Further research is essential to deepen understanding of PS-OSD interactions and develop effective therapies.
UNASSIGNED: Data from 213 PS patients at Sheba Medical Center were retrospectively analyzed, evaluating various OSD symptoms and treatment effectiveness through standardized clinical assessments and statistical tests.
UNASSIGNED: Predominantly older and female, many patients exhibited bilateral PS. OSD symptoms were found in 35.2% of all patients. Treatments like punctoplasty with stents significantly alleviated symptoms. Significant associations between treatment modalities and symptom improvement were identified.
UNASSIGNED: PS and OSD have acomplex, bidirectional relationship that complicates treatment outcomes. This study underscores the need for thorough diagnostic approaches and personalized treatments to improve PS management. Further research is essential to deepen understanding of PS-OSD interactions and develop effective therapies.
摘要：
■本研究探讨了获得性泪点狭窄（PS）与眼表疾病（OSD）之间的关系，评估因果机制和临床影响，结合全面的文献回顾和对三级医疗中心的患者队列的详细分析。
■对来自Sheba医疗中心的213例PS患者的数据进行了回顾性分析，通过标准化临床评估和统计测试评估各种OSD症状和治疗效果。
■主要是年长和女性，许多患者表现为双侧PS。35.2%的患者出现OSD症状。诸如用支架进行的点滴成形术的治疗显著缓解了症状。确定了治疗方式与症状改善之间的显着关联。
■PS和OSD具有复杂性，使治疗结果复杂化的双向关系。这项研究强调了全面的诊断方法和个性化治疗以改善PS管理的必要性。进一步的研究对于加深对PS-OSD相互作用的理解和开发有效的疗法至关重要。
■对来自Sheba医疗中心的213例PS患者的数据进行了回顾性分析，通过标准化临床评估和统计测试评估各种OSD症状和治疗效果。
■主要是年长和女性，许多患者表现为双侧PS。35.2%的患者出现OSD症状。诸如用支架进行的点滴成形术的治疗显著缓解了症状。确定了治疗方式与症状改善之间的显着关联。
■PS和OSD具有复杂性，使治疗结果复杂化的双向关系。这项研究强调了全面的诊断方法和个性化治疗以改善PS管理的必要性。进一步的研究对于加深对PS-OSD相互作用的理解和开发有效的疗法至关重要。
