Abstract：
The foreign body response (FBR) is an immune-mediated reaction that can occur with most biomaterials and biomedical devices. The FBR initiates a deterioration in the performance of implantable devices, representing a longstanding challenge that consistently hampers their optimal utilization. Over the last decade, significant strides are achieved based on either hydrogel design or surface modifications to mitigate the FBR. This review delves into recent material strategies aimed at mitigating the FBR. Further, the authors look forward to future novel anti-FBR materials from the perspective of clinical translation needs. Such prospective materials hold the potential to attenuate local immune responses, thereby significantly enhancing the overall performance of implantable devices.
摘要：
异物反应（FBR）是一种免疫介导的反应，可以在大多数生物材料和生物医学设备中发生。FBR导致植入式器械性能下降,这是一个长期的挑战，一直阻碍着它们的最佳利用。在过去的十年里，基于水凝胶设计或表面改性以减轻FBR已经实现了显著的进步。这篇综述深入研究了旨在减轻FBR的最新材料策略。此外，我们从临床翻译需求的角度期待未来新型的抗FBR材料。这种预期材料具有减弱局部免疫反应的潜力，从而显著提高可植入装置的整体性能。本文受版权保护。保留所有权利。
