PDF(Pubmed)
Abstract：
Acquired tubulopathies are frequently underdiagnosed. They can be characterized by the renal loss of specific electrolytes or organic solutes, suggesting the location of dysfunction. These tubulopathies phenotypically can resemble Bartter or Gitelman syndrome). These syndromes are infrequent, they may present salt loss resembling the effect of thiazides (Gitelman) or loop diuretics (Bartter). They are characterized by potentially severe hypokalemia, associated with metabolic alkalosis, secondary hyperaldosteronism, and often hypomagnesemia. Tubular dysfunction has been described as nephrotoxic effects of platinum-based chemotherapy. We present 4 cases with biochemical signs of tubular dysfunction (Bartter-like/Gitelman-like phenotype) related to chemotherapy.
摘要：
获得性肾小管疾病经常被诊断不足。它们的特征在于特定电解质或有机溶质的肾脏损失，提示功能障碍的位置。这些肾小管病变的表型可能类似于Bartter或Gitelman综合征）。这些综合症很少见，它们可能表现出类似于噻嗪类（Gitelman）或环状利尿剂（Bartter）的盐分损失。他们的特点是潜在的严重低钾血症，与代谢性碱中毒有关，继发性醛固酮增多症,经常是低镁血症。肾小管功能障碍已被描述为基于铂的化疗的肾毒性作用。我们介绍了4例与化疗相关的肾小管功能障碍（Bartter样/Gitelman样表型）的生化体征。
