PDF(Pubmed)
Abstract：
Osteosarcoma is the most common type of primary bone cancer, which usually appears in the distal femur. The diagnosis of this condition typically involves advanced imaging and tissue biopsy, as well as taking into account characteristic clinical and radiographic indicators. The treatment approach for distal femoral osteosarcoma is multidisciplinary and involves initial chemotherapy, followed by limb-sparing surgery, reconstruction of bone and soft tissue, and subsequent adjuvant chemotherapy. We present a case study of a 25-year-old male admitted with a blastic lesion in the distal femur, confirmed via open biopsy to be osteoblastic osteosarcoma. Further evaluation revealed multiple pulmonary nodular lesions, managed with chemotherapy. After four months, regression of the lesion was observed. Due to malignant clinical and imaging features, excision of the lesion and subsequent reconstruction were performed, utilizing a custom-made total knee arthroplasty. The excision encompassed the removal of the distal 14 cm of the femur, with histological examination confirming central osteoblastic osteosarcoma. Satisfactory outcomes were observed during a one-year follow-up, indicating promising results. Vigilance is crucial, especially in young patients with surface-type bone tumors, as this neoplasm requires consideration.
摘要：
骨肉瘤是最常见的原发性骨癌，通常出现在股骨远端。这种情况的诊断通常涉及高级成像和组织活检，以及考虑到特征性的临床和影像学指标。股骨远端骨肉瘤的治疗方法是多学科的，涉及初始化疗，接着是保肢手术,骨和软组织重建，以及随后的辅助化疗。我们提供了一个案例研究，该案例研究涉及一名25岁的男性，该男性在股骨远端患有疱疹性病变，通过开放活检证实是成骨细胞骨肉瘤。进一步评估显示肺部多发结节病变，用化疗管理。四个月后,观察到病变的消退。由于恶性的临床和影像学特征，切除病变并随后进行重建，利用定制的全膝关节置换术。切除包括去除股骨远端14厘米，组织学检查证实中央成骨细胞骨肉瘤。在一年的随访中观察到满意的结果，表明有希望的结果。警惕至关重要,尤其是年轻的表面型骨肿瘤患者，因为这个肿瘤需要考虑。
