PDF(Pubmed)
Abstract：
Toxoplasmosis is a pathological condition induced by the parasite, Toxoplasma gondii (T. gondii), which has a notable affinity for the cellular components of the central nervous system. Over the decades, the relationship between toxoplasmosis and the development of psychiatric disorders has generated profound interest within the scientific community. Whether considering immunocompetent or immunocompromised patients, epidemiological studies suggest that exposure to T. gondii may be associated with a higher risk of certain psychiatric disorders. However, there are extensive debates regarding the exact nature of this association and how T. gondii is involved in the pathogenesis of these disorders. Toxoplasmosis has long been considered an asymptomatic infection among immunocompetent patients. However, there appears to be an association between chronic brain infection with T. gondii and alterations in patient neuronal architecture, neurochemistry and behavior. The present review aimed to compile statements and pathophysiological hypotheses regarding the potential association between toxoplasmosis and psychotic disorders. Further research is necessary for understanding the potential relationship of T. gondii infection and psychotic disorders.
摘要：
弓形虫病是由寄生虫引起的一种病理状况，弓形虫(T.gondii),对中枢神经系统的细胞成分具有明显的亲和力。几十年来,弓形虫病与精神疾病发展之间的关系在科学界引起了极大的兴趣。无论是考虑有免疫能力还是免疫功能低下的患者，流行病学研究表明，暴露于弓形虫可能与某些精神疾病的高风险有关。然而,关于这种关联的确切性质以及弓形虫如何参与这些疾病的发病机制，存在广泛的争论。弓形虫病长期以来被认为是免疫功能正常的患者中的无症状感染。然而,弓形虫的慢性脑感染与患者神经元结构的改变之间似乎存在关联，神经化学和行为。本综述旨在汇编有关弓形虫病与精神病之间潜在关联的陈述和病理生理学假设。进一步的研究对于了解弓形虫感染和精神病的潜在关系是必要的。
