PDF(Pubmed)
Abstract：
As one member of the heterogeneous ribonucleoprotein (hnRNP) family, scaffold attachment factor A (SAF-A) or hnRNP U, is an abundant nuclear protein. With RNA and DNA binding activities, SAF-A has multiple functions. The present review focused on the biological structure and different roles of SAF-A and SAF-A-related diseases. It was found that SAF-A maintains the higher-order chromatin organization via RNA and DNA, and regulates transcription at the initiation and elongation stages. In addition to regulating pre-mRNA splicing, mRNA transportation and stabilization, SAF-A participates in double-strand breaks and mitosis repair. Therefore, the aberrant expression and mutation of SAF-A results in tumors and impaired neurodevelopment. Moreover, SAF-A may play a role in the anti-virus system. In conclusion, due to its essential biological functions, SAF-A may be a valuable clinical prediction factor or therapeutic target. Since the role of SAF-A in tumors and viral infections may be controversial, more animal experiments and clinical assays are needed.
摘要：
作为异质核糖核蛋白（hnRNP）家族的成员之一，支架附着因子A（SAF-A）或hnRNPU，是一种丰富的核蛋白。具有RNA和DNA结合活性，SAF-A具有多种功能。本文就SAF-A和SAF-A相关疾病的生物学结构和不同作用作一综述。发现SAF-A通过RNA和DNA维持高级染色质组织，并在起始和延伸阶段调节转录。除了调节pre-mRNA剪接，mRNA运输和稳定，SAF-A参与双链断裂和有丝分裂修复。因此,SAF-A的异常表达和突变导致肿瘤和神经发育受损。此外，SAF-A可能在抗病毒系统中发挥作用。总之,由于其基本的生物学功能，SAF-A可能是有价值的临床预测因子或治疗靶标。由于SAF-A在肿瘤和病毒感染中的作用可能存在争议，需要更多的动物实验和临床试验。
