PDF(Pubmed)
Abstract：
In hypothyroid patients needing large doses of levothyroxine (L-T4) (>1.7-2 μg/kg/day) to reach euthyroidism, lactose intolerance (LI) needs to be excluded, owing to the high prevalence in the population. If LI is present, a lactose-free diet decreases the rate of L-T4 malabsorption. However, an increased requirement of L-T4 is described in patients with LI, which can be beneficially treated using lactose-free L-T4 formulation. The lactose-free liquid L-T4 formulation is able to circumvent LI malabsorption leading to the normalization of thyroid-stimulating hormone (TSH) in patients with subclinical hypothyroidism and long-term stable TSH levels.
摘要：
在需要大剂量左甲状腺素（L-T4）（>1.7-2μg/kg/天）以达到甲状腺功能正常的甲状腺功能减退患者中，乳糖不耐受（LI）需要排除，由于人口中的高患病率。如果LI在场,无乳糖饮食可降低L-T4吸收不良的发生率。然而,LI患者对L-T4的需求增加，其可以使用无乳糖的L-T4制剂有益地处理。无乳糖液体L-T4制剂能够避免LI吸收不良,导致亚临床甲状腺功能减退症和TSH水平长期稳定的患者的促甲状腺激素(TSH)正常化。
