PDF(Pubmed)
Abstract：
UNASSIGNED: Oral squamous cell carcinoma is the most prevalent malignancy in the oral cavity, with a significant mortality rate. In oral squamous cell carcinoma patients, the survival rate could decrease because of delayed diagnosis. Thus, prevention, early diagnosis, and appropriate treatment can effectively increase the survival rate in patients. In this systematic review, we discussed the role of different genes in oral squamous cell carcinoma metastasis. Herein, we aimed to summarize clinical results, regarding the potential genes that promote oral squamous cell carcinoma metastasis.
UNASSIGNED: This systematic review was carried out under the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. An electronic search for all relevant articles published in English between January 2018 and April 2022 was performed using Scopus, PubMed, and Google Scholar search engines. All original studies published in English were included, and we excluded studies that were in a non-English language.
UNASSIGNED: A total of 4682 articles were found, of which 14 were relevant and detected significant genes in oral squamous cell carcinoma progression. These findings investigated the overexpression of interferon-induced proteins with tetratricopeptide repeats 1 and 3 (IFIT1, IFT3), high-mobility group A2 (HMGA2), transformed growth factor-beta-induced, lectin galactoside-binding soluble 3 binding protein (LGALS3BP), bromodomain containing 4, COP9 signaling complex 6, heterogeneous nuclear ribonucleoproteins A2B1 (HNRNPA2B1), 5\'-3\' exoribonuclease 2 (XRN2), cystatin-A (CSTA), fibroblast growth factors 8 (FGF8), forkhead box P3, cadherin-3, also known as P-cadherin and Wnt family member 5A, ubiquitin-specific-processing protease 7, and retinoic acid receptor responder protein 2 genes lead to promote metastasis in oral squamous cell carcinoma. Overexpression of some genes (IFIT1, 3, LGALS3BP, HMGA2, HNRNPA2B1, XRN2, CSTA, and FGF8) was proven to be correlated with poor survival rates in oral squamous cell carcinoma patients.
UNASSIGNED: Studies suggest that metastatic genes indicate a poor prognosis for oral squamous cell carcinoma patients. Detecting these metastatic genes in oral squamous cell carcinoma patients may be of predictive value and can also facilitate assessing oral squamous cell carcinoma development and its response to treatment.
UNASSIGNED: This systematic review was carried out under the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. An electronic search for all relevant articles published in English between January 2018 and April 2022 was performed using Scopus, PubMed, and Google Scholar search engines. All original studies published in English were included, and we excluded studies that were in a non-English language.
UNASSIGNED: A total of 4682 articles were found, of which 14 were relevant and detected significant genes in oral squamous cell carcinoma progression. These findings investigated the overexpression of interferon-induced proteins with tetratricopeptide repeats 1 and 3 (IFIT1, IFT3), high-mobility group A2 (HMGA2), transformed growth factor-beta-induced, lectin galactoside-binding soluble 3 binding protein (LGALS3BP), bromodomain containing 4, COP9 signaling complex 6, heterogeneous nuclear ribonucleoproteins A2B1 (HNRNPA2B1), 5\'-3\' exoribonuclease 2 (XRN2), cystatin-A (CSTA), fibroblast growth factors 8 (FGF8), forkhead box P3, cadherin-3, also known as P-cadherin and Wnt family member 5A, ubiquitin-specific-processing protease 7, and retinoic acid receptor responder protein 2 genes lead to promote metastasis in oral squamous cell carcinoma. Overexpression of some genes (IFIT1, 3, LGALS3BP, HMGA2, HNRNPA2B1, XRN2, CSTA, and FGF8) was proven to be correlated with poor survival rates in oral squamous cell carcinoma patients.
UNASSIGNED: Studies suggest that metastatic genes indicate a poor prognosis for oral squamous cell carcinoma patients. Detecting these metastatic genes in oral squamous cell carcinoma patients may be of predictive value and can also facilitate assessing oral squamous cell carcinoma development and its response to treatment.
摘要：
■口腔鳞状细胞癌是口腔中最常见的恶性肿瘤，死亡率很高。在口腔鳞状细胞癌患者中，由于诊断延迟，生存率可能会降低。因此，预防,早期诊断,适当的治疗可以有效提高患者的生存率。在这次系统审查中，我们讨论了不同基因在口腔鳞状细胞癌转移中的作用。在这里，我们旨在总结临床结果，关于促进口腔鳞状细胞癌转移的潜在基因。
本系统评价是在系统评价和荟萃分析指南的首选报告项目下进行的。使用Scopus对2018年1月至2022年4月之间以英语发布的所有相关文章进行了电子搜索。PubMed,和谷歌学者搜索引擎。所有以英文发表的原始研究都包括在内，我们排除了非英语语言的研究。
■共发现4682篇文章，其中14个与口腔鳞状细胞癌进展相关并检测到显著基因。这些发现调查了干扰素诱导的蛋白质与四三肽重复1和3（IFIT1，IFT3）的过度表达，高迁移率组A2(HMGA2)，转化生长因子-β诱导，凝集素半乳糖苷结合可溶性3结合蛋白（LGALS3BP），含溴结构域4，COP9信号复合物6，异质核核糖核蛋白A2B1（HNRNPA2B1），5'-3'外切核糖核酸酶2（XRN2），胱抑素A(CSTA),成纤维细胞生长因子8（FGF8），叉头盒P3，cadherin-3，也称为P-cadherin和Wnt家族成员5A，泛素特异性加工蛋白酶7和视黄酸受体应答蛋白2基因导致口腔鳞状细胞癌转移。一些基因的过表达（IFIT1，3，LGALS3BP，HMGA2，HNRNPA2B1，XRN2，CSTA，和FGF8）被证明与口腔鳞状细胞癌患者的低生存率相关。
■研究表明，转移基因提示口腔鳞状细胞癌患者预后不良。在口腔鳞状细胞癌患者中检测这些转移基因可能具有预测价值，并且还可以促进评估口腔鳞状细胞癌的发展及其对治疗的反应。
本系统评价是在系统评价和荟萃分析指南的首选报告项目下进行的。使用Scopus对2018年1月至2022年4月之间以英语发布的所有相关文章进行了电子搜索。PubMed,和谷歌学者搜索引擎。所有以英文发表的原始研究都包括在内，我们排除了非英语语言的研究。
■共发现4682篇文章，其中14个与口腔鳞状细胞癌进展相关并检测到显著基因。这些发现调查了干扰素诱导的蛋白质与四三肽重复1和3（IFIT1，IFT3）的过度表达，高迁移率组A2(HMGA2)，转化生长因子-β诱导，凝集素半乳糖苷结合可溶性3结合蛋白（LGALS3BP），含溴结构域4，COP9信号复合物6，异质核核糖核蛋白A2B1（HNRNPA2B1），5'-3'外切核糖核酸酶2（XRN2），胱抑素A(CSTA),成纤维细胞生长因子8（FGF8），叉头盒P3，cadherin-3，也称为P-cadherin和Wnt家族成员5A，泛素特异性加工蛋白酶7和视黄酸受体应答蛋白2基因导致口腔鳞状细胞癌转移。一些基因的过表达（IFIT1，3，LGALS3BP，HMGA2，HNRNPA2B1，XRN2，CSTA，和FGF8）被证明与口腔鳞状细胞癌患者的低生存率相关。
■研究表明，转移基因提示口腔鳞状细胞癌患者预后不良。在口腔鳞状细胞癌患者中检测这些转移基因可能具有预测价值，并且还可以促进评估口腔鳞状细胞癌的发展及其对治疗的反应。
