PDF(Pubmed)
Abstract：
OBJECTIVE: In the present study, we introduce human lacrimal gland imaging using an ultrasound biomicroscopy (UBM) with a soft cover and show their findings.
METHODS: The representative UBM findings of palpebral lobes in seven subjects (four with non-Sjögren dry eye syndrome, one with Sjögren syndrome, and two healthy subjects) were described in this study. To prolapse the palpebral lobe, the examiner pulled the temporal part of the upper eyelid in the superotemporal direction and directed the subject to look in the inferonasal direction. We scanned the palpebral lobes longitudinally and transversely using UBM. We used an Aviso UBM with a 50 MHz linear probe and ClearScan.
RESULTS: In UBM of two healthy subjects, the echogenicity of the lacrimal gland was lower than that of the sclera and homogeneous. But the parenchyma of a patient with Sjögren dry eye syndrome was quite inhomogeneous compared to the healthy subjects. In two patients with dry eye syndrome, we were able to observe some lobules in the parenchyma. We could find excretory ducts running parallel at the surface of the longitudinal section in some subjects. In the longitudinal UBM scan of a subject, we observed a tubular structure at a depth of 1,500 μm that was considered a blood vessel. It ran from the superonasal to the inferotemporal direction. In a subject, we observed a large cyst beneath the conjunctiva.
CONCLUSIONS: Lacrimal gland imaging using UBM has both advantages of optical coherence tomography and sonography, and could be useful for evaluating dry eye syndrome.
METHODS: The representative UBM findings of palpebral lobes in seven subjects (four with non-Sjögren dry eye syndrome, one with Sjögren syndrome, and two healthy subjects) were described in this study. To prolapse the palpebral lobe, the examiner pulled the temporal part of the upper eyelid in the superotemporal direction and directed the subject to look in the inferonasal direction. We scanned the palpebral lobes longitudinally and transversely using UBM. We used an Aviso UBM with a 50 MHz linear probe and ClearScan.
RESULTS: In UBM of two healthy subjects, the echogenicity of the lacrimal gland was lower than that of the sclera and homogeneous. But the parenchyma of a patient with Sjögren dry eye syndrome was quite inhomogeneous compared to the healthy subjects. In two patients with dry eye syndrome, we were able to observe some lobules in the parenchyma. We could find excretory ducts running parallel at the surface of the longitudinal section in some subjects. In the longitudinal UBM scan of a subject, we observed a tubular structure at a depth of 1,500 μm that was considered a blood vessel. It ran from the superonasal to the inferotemporal direction. In a subject, we observed a large cyst beneath the conjunctiva.
CONCLUSIONS: Lacrimal gland imaging using UBM has both advantages of optical coherence tomography and sonography, and could be useful for evaluating dry eye syndrome.
摘要：
■在本研究中，我们使用带有软盖的超声生物显微镜（UBM）介绍人类泪腺成像，并显示其发现。
■7名受试者（4名非干燥型干眼综合征，1患有干燥综合征，和2名健康受试者)在这项研究中进行了描述。为了脱垂眼睑叶，检查者将上眼睑的颞部拉向上颞部，并指示受试者向鼻下方向看。我们使用UBM纵向和横向扫描了睑叶。我们使用了阿维索UBM(QuantelMedical，克莱蒙费朗,法国），带有50MHz线性探头和ClearScan。
■在两个健康受试者的UBM中，泪腺的回声低于巩膜且均匀。但是,与健康受试者相比,Sjögren干眼综合征患者的实质非常不均匀.在两名干眼症患者中，我们能够观察到薄壁组织中的一些小叶。在某些受试者中，我们可以发现排泄管道在纵向截面的表面平行延伸。在受试者的纵向UBM扫描中，我们观察到1500µm深度的管状结构被认为是血管。它从鼻上方向跑到下流方向。在一个主题中，我们观察到结膜下有一个大囊肿。
■使用UBM进行泪腺成像具有OCT和超声检查的优点，并可用于评估干眼症。
■7名受试者（4名非干燥型干眼综合征，1患有干燥综合征，和2名健康受试者)在这项研究中进行了描述。为了脱垂眼睑叶，检查者将上眼睑的颞部拉向上颞部，并指示受试者向鼻下方向看。我们使用UBM纵向和横向扫描了睑叶。我们使用了阿维索UBM(QuantelMedical，克莱蒙费朗,法国），带有50MHz线性探头和ClearScan。
■在两个健康受试者的UBM中，泪腺的回声低于巩膜且均匀。但是,与健康受试者相比,Sjögren干眼综合征患者的实质非常不均匀.在两名干眼症患者中，我们能够观察到薄壁组织中的一些小叶。在某些受试者中，我们可以发现排泄管道在纵向截面的表面平行延伸。在受试者的纵向UBM扫描中，我们观察到1500µm深度的管状结构被认为是血管。它从鼻上方向跑到下流方向。在一个主题中，我们观察到结膜下有一个大囊肿。
■使用UBM进行泪腺成像具有OCT和超声检查的优点，并可用于评估干眼症。
