Abstract：
The use of polyetheretherketone (PEEK) for cementless femoral total knee arthroplasty (TKA) components is of interest due to several potential advantages, e.g. the use in patients with metal hypersensitivity. Additionally, the stiffness of PEEK closer resembles the stiffness of bone, and therefore, peri-prosthetic stress-shielding may be avoided. When introducing a new implant material for cementless TKA designs, it is important to study its effect on the primary fixation, which is required for the long-term fixation. Finite element (FE) studies can be used to study the effect of PEEK as implant material on the primary fixation, which may be dependent on patient factors such as age, gender and body weight index (BMI). Therefore, the research objectives of this study were to investigate the effect of PEEK vs cobalt-chrome (CoCr) and patient characteristics on the primary fixation of a cementless femoral component. 280 FE models of 70 femora were created with varying implant material and gait and squat activity. Overall, the PEEK models generated larger peak micromotions than the CoCr models. Distinct differences were seen in the micromotion distributions between the PEEK and CoCr models for both the gait and squat models. The micromotions of all femoral models significantly increased with BMI. Neither gender nor age of the patients had a significant effect on the micromotions. This population study gives insights into the primary fixation of a cementless femoral component in a cohort of FE models with varying implant material and patient characteristics.
摘要：
将聚醚醚酮（PEEK）用于无骨水泥型股骨全膝关节置换术（TKA）组件是令人感兴趣的，例如在金属超敏反应患者中的使用。此外,PEEK闭合器的刚度类似于骨骼的刚度，因此,可以避免假体周围的应力屏蔽。当引入一种新的植入材料用于非水泥TKA设计时，重要的是研究它对主要固定的影响，这是长期固定所必需的。有限元（FE）研究可用于研究PEEK作为植入材料对主要固定的影响，这可能取决于患者的因素，如年龄，性别和体重指数（BMI）。因此,本研究的研究目的是探讨PEEK与钴铬合金(CoCr)和患者特征对非骨水泥股骨构件初次固定的影响.使用不同的植入材料以及步态和下蹲活动创建了280个70个股骨的FE模型。总的来说,PEEK模型比CoCr模型产生更大的峰值微运动。对于步态和蹲模型，PEEK和CoCr模型之间的微动分布存在明显差异。所有股骨模型的微运动均随BMI的增加而显着增加。患者的性别和年龄对微运动均无明显影响。这项人群研究在一组具有不同植入物材料和患者特征的FE模型中，对无骨水泥股骨部件的主要固定进行了深入的了解。
