Abstract：
Runting and stunting syndrome (RSS) is an enteric viral disease in commercial poultry that directly affects gut health; however, its influence on gut microbiota remains unknown. This study aimed to investigate the compositional changes in the bacterial community of the ileum of 7-day-old broiler chicks naturally affected or not affected by RSS, using next-generation sequencing (NGS) technology. Twenty-one samples were obtained from the ileal contents and mucosa of 11 chicks with RSS and 10 healthy chicks, raised in a dark house system located on a farm in the state of Minas Gerais, Brazil. The results revealed overall changes in the gut microbiota of the chicks with RSS, including a decrease in microbial richness and diversity. In particular, there was a decrease in Lactobacillus and an increase in Candidatus Arthromitus and Clostridium sensu stricto 1. These results indicate a relationship between viral infection and the gut microbial composition, which can cause gut dysbiosis and may influence inflammation in this organ.RESEARCH HIGHLIGHTS RSS causes dysbiosis of the gut microbiota of the ilea of chicks.A difference was found in gut microbiota between chicks with or without RSS.Candidatus Arthromitus was predominant in chicks with RSS.Clostridium sensu stricto 1 was strictly associated with chicks with RSS.
摘要：
长跑和发育迟缓综合征（RSS）是一种肠道病毒疾病，在商业家禽，直接影响肠道健康;然而，它对肠道微生物群的影响仍然未知。本研究旨在调查7天大的肉鸡回肠细菌群落的组成变化，这些细菌群落自然受RSS的影响而不受RSS的影响。使用下一代测序（NGS）技术。从11只具有RSS的雏鸡和10只健康雏鸡的回肠内容物和粘膜中获得21个样本，在米纳斯吉拉斯州一个农场的黑暗房屋系统中长大，巴西。结果揭示了具有RSS的雏鸡的肠道微生物群的总体变化，包括微生物丰富度和多样性的减少。特别是,乳杆菌减少，念珠菌和敏感梭菌1增加。这些结果表明病毒感染和肠道微生物组成之间的关系，这可能导致肠道菌群失调，并可能影响该器官的炎症。研究概述SRSS导致雏鸡肠梗阻的肠道微生物群生态失调。在有和没有RSS的雏鸡之间的肠道微生物群中发现了差异。在RSS的雏鸡中，念珠菌占优势。严格意义梭状芽孢杆菌1与具有RSS的雏鸡严格相关。
