Abstract：
Objective: This study aims to explore the preventive potential of photobiomodulation (PBM) in bisphosphonate-related osteonecrosis of the jaw (BRONJ) using a rat model. Methods: An experimental rat model was established, exposing rats to zoledronic acid (ZA), a primary risk factor for BRONJ. An 810 nm diode laser was applied with parameters of 0.33 W/cm2 power density and 10 J/cm2 energy density for 30 sec. PBM was initiated 1 day pre-extraction and continued for 2 weeks. The impact of PBM on wound healing in both soft and hard tissues was evaluated post tooth extraction. Results: ZA exposure hindered wound healing in both soft and hard tissues after tooth extraction. PBM intervention effectively mitigated the adverse effects of ZA, promoting healing processes in both tissue types. This suggests the potential of PBM as a preventive strategy for BRONJ in patients on long-term bisphosphonate treatment. Moreover, PBM exhibited enhanced wound healing in normal rats, indicating its broader applicability beyond BRONJ cases. Conclusions: PBM shows promise in preventing and improving wound healing in BRONJ and normal cases. These findings underscore the significance of optimizing PBM parameters and suggest its potential clinical relevance as a preventive intervention for BRONJ and a promoter of wound healing.
摘要：
目的:本研究旨在使用大鼠模型探讨光生物调节(PBM)在双膦酸盐相关性颌骨坏死(BRONJ)中的预防潜力。方法:建立实验性大鼠模型,将大鼠暴露于唑来膦酸（ZA），BRONJ的主要危险因素。以0.33W/cm2功率密度和10J/cm2能量密度的参数施加810nm二极管激光器30秒。PBM在提取前1天开始并持续2周。拔牙后评估PBM对软组织和硬组织伤口愈合的影响。结果：ZA暴露会阻碍拔牙后软组织和硬组织的伤口愈合。PBM干预有效缓解了ZA的不良影响，促进两种组织类型的愈合过程。这表明PBM作为长期双膦酸盐治疗患者BRONJ的预防策略的潜力。此外，PBM在正常大鼠中表现出增强的伤口愈合，表明其在BRONJ病例之外的更广泛适用性。结论：PBM在预防和改善BRONJ和正常情况下的伤口愈合方面显示出希望。这些发现强调了优化PBM参数的重要性，并表明其作为BRONJ的预防性干预和伤口愈合的促进剂的潜在临床相关性。
