Abstract：
Selenium is an essential trace element that is delivered to the brain by the selenium transport protein selenoprotein P (SEPP1), primarily by binding to its receptor low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), at the blood-brain barrier. Selenium transport is required for several important brain functions, with transgenic deletion of either Sepp1 or Lrp8 resulting in severe neurological dysfunction and death in mice fed a selenium-deficient diet. Previous studies have reported that although feeding a standard chow diet can prevent these severe deficits, some motor coordination and cognitive dysfunction remain. Importantly, no single study has directly compared the motor and cognitive performance of the Sepp1 and Lrp8 knockout (KO) lines. Here, we report the results of a comprehensive parallel analysis of the motor and spatial learning and memory function of Sepp1 and Lrp8 knockout mice fed a standard mouse chow diet. Our results revealed that Sepp1 knockout mice raised on a selenium-replete diet displayed motor and cognitive function that was indistinguishable from their wild-type littermates. In contrast, we found that although Lrp8-knockout mice fed a selenium-replete diet had normal motor function, their spatial learning and memory showed subtle deficits. We also found that the deficit in baseline adult hippocampal neurogenesis exhibited by Lrp8-deficit mice could not be rescued by dietary selenium supplementation. Taken together, these findings further highlight the importance of selenium transport in maintaining healthy brain function. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
摘要：
硒是一种必需的微量元素，通过硒转运蛋白硒蛋白P（SEPP1）输送到大脑，主要通过结合其受体低密度脂蛋白受体相关蛋白8（LRP8），也称为载脂蛋白E受体2（ApoER2），在血脑屏障上.硒运输是几个重要的大脑功能所必需的，Sepp1或Lrp8的转基因缺失导致硒缺乏饮食的小鼠严重的神经功能障碍和死亡。以前的研究报告说，尽管喂食标准的食物可以防止这些严重的缺陷，一些运动协调和认知功能障碍仍然存在。重要的是,没有一项研究直接比较了Sepp1和Lrp8基因敲除（KO）系的运动和认知表现。这里,我们报告了对喂食标准小鼠食物饮食的Sepp1和Lrp8基因敲除小鼠的运动和空间学习和记忆功能进行综合平行分析的结果。我们的结果表明，在硒充足的饮食中饲养的Sepp1敲除小鼠表现出的运动和认知功能与野生型同窝动物没有区别。相比之下,我们发现，尽管饲喂硒充足饮食的Lrp8基因敲除小鼠具有正常的运动功能，他们的空间学习和记忆表现出微妙的缺陷。我们还发现，Lrp8缺陷小鼠表现出的基线成年海马神经发生缺陷不能通过饮食硒补充来挽救。一起来看,这些发现进一步强调了硒运输对维持健康大脑功能的重要性。（PsycInfo数据库记录（c）2024APA，保留所有权利)。
