PDF(Pubmed)
Abstract：
Cutaneous diseases (such as atopic dermatitis, acne, psoriasis, alopecia and chronic wounds) rank as the fourth most prevalent human disease, affecting nearly one-third of the world\'s population. Skin diseases contribute to significant non-fatal disability globally, impacting individuals, partners, and society at large. Recent evidence suggests that specific microbes colonising our skin and its appendages are often overrepresented in disease. Therefore, manipulating interactions of the microbiome in a non-invasive and safe way presents an attractive approach for management of skin and hair follicle conditions. Due to its proven anti-microbial and anti-inflammatory effects, blue light (380 - 495nm) has received considerable attention as a possible \'magic bullet\' for management of skin dysbiosis. As humans, we have evolved under the influence of sun exposure, which comprise a significant portion of blue light. A growing body of evidence indicates that our resident skin microbiome possesses the ability to detect and respond to blue light through expression of chromophores. This can modulate physiological responses, ranging from cytotoxicity to proliferation. In this review we first present evidence of the diverse blue light-sensitive chromophores expressed by members of the skin microbiome. Subsequently, we discuss how blue light may impact the dialog between the host and its skin microbiome in prevalent skin and hair follicle conditions. Finally, we examine the constraints of this non-invasive treatment strategy and outline prospective avenues for further research. Collectively, these findings present a comprehensive body of evidence regarding the potential utility of blue light as a restorative tool for managing prevalent skin conditions. Furthermore, they underscore the critical unmet need for a whole systems approach to comprehend the ramifications of blue light on both host and microbial behaviour.
摘要：
皮肤疾病（如特应性皮炎，痤疮,牛皮癣,脱发和慢性伤口)是第四大最常见的人类疾病，影响了世界近三分之一的人口。皮肤病在全球范围内导致严重的非致命残疾，影响个人，合作伙伴,和整个社会。最近的证据表明，在我们的皮肤及其附属物中定居的特定微生物通常在疾病中占主导地位。因此,以非侵入性和安全的方式操纵微生物组的相互作用为皮肤和毛囊状况的管理提供了有吸引力的方法。由于其已证明的抗微生物和抗炎作用，蓝光（380-495nm）作为管理皮肤生态失调的可能的“魔术子弹”受到了相当大的关注。作为人类,我们在阳光照射的影响下进化，其中包含了很大一部分蓝光。越来越多的证据表明，我们的常驻皮肤微生物组具有通过发色团的表达来检测和响应蓝光的能力。这可以调节生理反应，从细胞毒性到增殖。在这篇综述中，我们首先提出了皮肤微生物组成员表达的不同蓝光敏感发色团的证据。随后，我们讨论了在皮肤和毛囊普遍的情况下，蓝光如何影响宿主与其皮肤微生物组之间的对话。最后,我们研究了这种非侵入性治疗策略的局限性,并概述了进一步研究的前瞻性途径.总的来说，这些发现提供了关于蓝光作为治疗普遍皮肤状况的修复工具的潜在效用的全面证据。此外，他们强调了对理解蓝光对宿主和微生物行为的影响的整个系统方法的关键未满足需求。
