PDF(Pubmed)
Abstract：
This study aims to explore the association between outdoor artificial light at night (ALAN) exposure and gestational diabetes mellitus (GDM).
This study is a retrospective case-control study. According with quantiles, ALAN has been classified into three categories (Q1-Q3). GDM was diagnosed through oral glucose tolerance tests. Conditional logistic regression models were used to evaluate the association between ALAN exposure and GDM risk. The odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Restricted cubic spline analysis (RCS) was utilized to investigate the no liner association between ALAN and GDM.
A total of 5,720 participants were included, comprising 1,430 individuals with GDM and 4,290 matched controls. Pregnant women exposed to higher levels of ALAN during the first trimester exhibited an elevated risk of GDM compared to those with lower exposure levels (Q2 OR = 1.39, 95% CI 1.20-1.63, p < 0.001); (Q3 OR = 1.70, 95% CI 1.44-2.00, p < 0.001). Similarly, elevated ALAN exposure during the second trimester also conferred an increased risk of GDM (second trimester: Q2 OR = 1.70, 95% CI 1.45-1.98, p < 0.001; Q3 OR = 2.08, 95% CI 1.77-2.44, p < 0.001). RCS showed a nonlinear association between ALAN exposure and GDM risk in second trimester pregnancy, with a threshold value of 4.235.
Outdoor ALAN exposure during pregnancy is associated with an increased risk of GDM.
This study is a retrospective case-control study. According with quantiles, ALAN has been classified into three categories (Q1-Q3). GDM was diagnosed through oral glucose tolerance tests. Conditional logistic regression models were used to evaluate the association between ALAN exposure and GDM risk. The odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Restricted cubic spline analysis (RCS) was utilized to investigate the no liner association between ALAN and GDM.
A total of 5,720 participants were included, comprising 1,430 individuals with GDM and 4,290 matched controls. Pregnant women exposed to higher levels of ALAN during the first trimester exhibited an elevated risk of GDM compared to those with lower exposure levels (Q2 OR = 1.39, 95% CI 1.20-1.63, p < 0.001); (Q3 OR = 1.70, 95% CI 1.44-2.00, p < 0.001). Similarly, elevated ALAN exposure during the second trimester also conferred an increased risk of GDM (second trimester: Q2 OR = 1.70, 95% CI 1.45-1.98, p < 0.001; Q3 OR = 2.08, 95% CI 1.77-2.44, p < 0.001). RCS showed a nonlinear association between ALAN exposure and GDM risk in second trimester pregnancy, with a threshold value of 4.235.
Outdoor ALAN exposure during pregnancy is associated with an increased risk of GDM.
摘要：
■本研究旨在探讨夜间室外人造光（ALAN）暴露与妊娠期糖尿病（GDM）之间的关联。
■本研究为回顾性病例对照研究。根据分位数，ALAN已分为三类（Q1-Q3）。通过口服葡萄糖耐量试验诊断GDM。使用条件逻辑回归模型评估ALAN暴露与GDM风险之间的关系。使用比值比（OR）和95％置信区间（CI）评估相关性。限制性三次样条分析（RCS）用于研究ALAN和GDM之间的无线性关联。
■总共包括5,720名参与者，包括1,430名GDM患者和4,290名匹配的对照。与暴露水平较低的孕妇相比，在妊娠早期暴露于较高水平的ALAN的孕妇患GDM的风险较高（Q2OR=1.39，95％CI1.20-1.63，p<0.001）；（Q3OR=1.70，95％CI1.44-2.00，p<0.001）。同样，妊娠中期ALAN暴露升高也导致GDM风险增加(妊娠中期:Q2OR=1.70,95%CI1.45-1.98,p<0.001;Q3OR=2.08,95%CI1.77-2.44,p<0.001).RCS显示ALAN暴露与妊娠中期GDM风险之间存在非线性关联，阈值为4.235。
■怀孕期间的室外ALAN暴露与GDM风险增加有关。
■本研究为回顾性病例对照研究。根据分位数，ALAN已分为三类（Q1-Q3）。通过口服葡萄糖耐量试验诊断GDM。使用条件逻辑回归模型评估ALAN暴露与GDM风险之间的关系。使用比值比（OR）和95％置信区间（CI）评估相关性。限制性三次样条分析（RCS）用于研究ALAN和GDM之间的无线性关联。
■总共包括5,720名参与者，包括1,430名GDM患者和4,290名匹配的对照。与暴露水平较低的孕妇相比，在妊娠早期暴露于较高水平的ALAN的孕妇患GDM的风险较高（Q2OR=1.39，95％CI1.20-1.63，p<0.001）；（Q3OR=1.70，95％CI1.44-2.00，p<0.001）。同样，妊娠中期ALAN暴露升高也导致GDM风险增加(妊娠中期:Q2OR=1.70,95%CI1.45-1.98,p<0.001;Q3OR=2.08,95%CI1.77-2.44,p<0.001).RCS显示ALAN暴露与妊娠中期GDM风险之间存在非线性关联，阈值为4.235。
■怀孕期间的室外ALAN暴露与GDM风险增加有关。
