PDF(Pubmed)
Abstract：
The emergence of antimicrobial resistance among biofilm forming pathogens aimed to search for the efficient and novel alternative strategies. Metallic nanoparticles have drawn a considerable attention because of their significant applications in various fields. Numerous methods are developed for the generation of these nanoparticles however, mycogenic (fungal-mediated) synthesis is attractive due to high yields, easier handling, eco-friendly and being energy efficient when compared with conventional physico-chemical methods. Moreover, mycogenic synthesis provides fungal derived biomolecules that coat the nanoparticles thus improving their stability. The process of mycogenic synthesis can be extracellular or intracellular depending on the fungal genera used and various factors such as temperature, pH, biomass concentration and cultivation time may influence the synthesis process. This review focuses on the synthesis of metallic nanoparticles by using fungal mycelium, mechanism of synthesis, factors affecting the mycosynthesis and also describes their potential applications as antioxidants and antibiofilm agents. Moreover, the utilization of mycogenic nanoparticles as quorum quenching agent in hampering the bacterial cell-cell communication (quorum sensing) has also been discussed.
摘要：
生物膜形成病原体之间的抗微生物耐药性的出现旨在寻找有效和新颖的替代策略。金属纳米粒子由于其在各个领域的重要应用而引起了广泛的关注。然而，许多方法被开发用于生成这些纳米粒子，真菌（真菌介导的）合成由于高产量而具有吸引力，更容易处理，与传统的物理化学方法相比，环保且节能。此外，真菌合成提供了真菌衍生的生物分子，这些生物分子包被纳米颗粒，从而提高了它们的稳定性。真菌合成的过程可以是细胞外或细胞内的，这取决于所使用的真菌属和各种因素，如温度，pH值,生物量浓度和培养时间可能会影响合成过程。本文综述了利用真菌菌丝体合成金属纳米颗粒，合成机理，影响真菌合成的因素，并描述了它们作为抗氧化剂和抗生物膜剂的潜在应用。此外，还讨论了利用真菌纳米颗粒作为群体猝灭剂来阻碍细菌细胞间的通讯（群体感应）。
