PDF(Pubmed)
Abstract：
BACKGROUND: Hepatitis B rarely leads to demyelinating neuropathy, despite peripheral neuropathy being the first symptom of hepatitis B infection.
METHODS: A 64-year-old man presented with sensorimotor symptoms in multiple peripheral nerves. Serological testing showed that these symptoms were due to hepatitis B. After undergoing treatment involving intravenous immunoglobulin and an antiviral agent, there was a notable improvement in his symptoms.
CONCLUSIONS: Although hepatitis B virus (HBV) infection is known to affect hepatocytes, it is crucial to recognize the range of additional manifestations linked to this infection. The connection between long-term HBV infection and demyelinating neuropathy has seldom been documented; hence, prompt diagnostic and treatment are essential. The patient\'s positive reaction to immunoglobulin seems to be associated with production of the antigen-antibody immune complex.
METHODS: A 64-year-old man presented with sensorimotor symptoms in multiple peripheral nerves. Serological testing showed that these symptoms were due to hepatitis B. After undergoing treatment involving intravenous immunoglobulin and an antiviral agent, there was a notable improvement in his symptoms.
CONCLUSIONS: Although hepatitis B virus (HBV) infection is known to affect hepatocytes, it is crucial to recognize the range of additional manifestations linked to this infection. The connection between long-term HBV infection and demyelinating neuropathy has seldom been documented; hence, prompt diagnostic and treatment are essential. The patient\'s positive reaction to immunoglobulin seems to be associated with production of the antigen-antibody immune complex.
摘要：
背景：乙型肝炎很少导致脱髓鞘性神经病，尽管周围神经病变是乙型肝炎感染的首发症状。
方法：一名64岁的男性患者表现为多个周围神经的感觉运动症状。血清学测试表明，这些症状是由于乙肝后接受治疗包括静脉注射免疫球蛋白和抗病毒药物，他的症状有了显著的改善。
结论：尽管已知乙型肝炎病毒（HBV）感染会影响肝细胞，认识到与这种感染有关的其他表现的范围至关重要。长期HBV感染和脱髓鞘神经病之间的联系很少被记录;因此，及时的诊断和治疗至关重要。患者对免疫球蛋白的阳性反应似乎与抗原-抗体免疫复合物的产生有关。
方法：一名64岁的男性患者表现为多个周围神经的感觉运动症状。血清学测试表明，这些症状是由于乙肝后接受治疗包括静脉注射免疫球蛋白和抗病毒药物，他的症状有了显著的改善。
结论：尽管已知乙型肝炎病毒（HBV）感染会影响肝细胞，认识到与这种感染有关的其他表现的范围至关重要。长期HBV感染和脱髓鞘神经病之间的联系很少被记录;因此，及时的诊断和治疗至关重要。患者对免疫球蛋白的阳性反应似乎与抗原-抗体免疫复合物的产生有关。
