PDF(Pubmed)
Abstract：
BACKGROUND: Para-aortic lymph nodes (PALNs) are common sites for the regional spread of cervical squamous cell carcinoma (SCC).
METHODS: We report the case of a 36-year-old woman who presented with cervical SCC with multiple bulky PALNs, largest measured 4.5 cm × 5 cm × 10 cm. The patient was treated with radical intent with definitive chemoradiation using sequential dose-escalated adaptive radiotherapy, followed by maintenance chemotherapy. The patient achieved a complete response; she has been doing well since the completion of treatment with no evidence of the disease for 2 years.
CONCLUSIONS: Regardless of the size of PALN metastases of cervical carcinoma origin, it is still treatable (with radical intent) via concurrent chemoradiation. Adaptive radiotherapy allows dose escalation with minimal toxicity.
METHODS: We report the case of a 36-year-old woman who presented with cervical SCC with multiple bulky PALNs, largest measured 4.5 cm × 5 cm × 10 cm. The patient was treated with radical intent with definitive chemoradiation using sequential dose-escalated adaptive radiotherapy, followed by maintenance chemotherapy. The patient achieved a complete response; she has been doing well since the completion of treatment with no evidence of the disease for 2 years.
CONCLUSIONS: Regardless of the size of PALN metastases of cervical carcinoma origin, it is still treatable (with radical intent) via concurrent chemoradiation. Adaptive radiotherapy allows dose escalation with minimal toxicity.
摘要：
背景：主动脉旁淋巴结（PALN）是宫颈鳞状细胞癌（SCC）区域扩散的常见部位。
方法：我们报告了一例36岁女性患者，该患者表现为宫颈SCC伴多个大体积PALN，最大尺寸为4.5厘米×5厘米×10厘米。患者接受根治性治疗，使用序贯剂量递增适应性放疗进行确定性放化疗。其次是维持化疗。患者达到了完全的反应;自治疗完成以来，她一直表现良好，2年没有疾病的证据。
结论：无论宫颈癌起源的PALN转移的大小，它仍然可以通过同步放化疗治疗（具有激进的意图）。自适应放疗允许剂量递增且毒性最小。
方法：我们报告了一例36岁女性患者，该患者表现为宫颈SCC伴多个大体积PALN，最大尺寸为4.5厘米×5厘米×10厘米。患者接受根治性治疗，使用序贯剂量递增适应性放疗进行确定性放化疗。其次是维持化疗。患者达到了完全的反应;自治疗完成以来，她一直表现良好，2年没有疾病的证据。
结论：无论宫颈癌起源的PALN转移的大小，它仍然可以通过同步放化疗治疗（具有激进的意图）。自适应放疗允许剂量递增且毒性最小。
