PDF(Pubmed)
Abstract：
Hypervirulent Klebsiella pneumoniae (hvKP) has emerged as a novel variant of K. pneumoniae, exhibiting distinct phenotypic and genotypic characteristics that confer increased virulence and pathogenicity. It is not only responsible for nosocomial infections but also community-acquired infections, including liver abscesses, endophthalmitis, and meningitis, leading to significant morbidity and mortality. HvKP has been reported all over the world, but it is mainly prevalent in Asia Pacific, especially China. Moreover, hvKP can acquire carbapenemase genes resulting in the emergence of carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP), which possesses both high virulence and drug resistance capabilities. Consequently, CR-hvKP poses substantial challenges to infection control and presents serious threats to global public health. In this paper, we provide a comprehensive summary of the epidemiological characteristics, virulence factors, and mechanisms underlying carbapenem resistance in hvKP strains with the aim of offering valuable insights for practical prevention strategies as well as future research.
摘要：
高毒力肺炎克雷伯菌（hvKP）已成为肺炎克雷伯菌的一种新变种，表现出独特的表型和基因型特征，赋予增加的毒力和致病性。它不仅是医院感染的原因，也是社区获得性感染的原因，包括肝脓肿,眼内炎,和脑膜炎，导致显著的发病率和死亡率。HvKP在世界各地都有报道，但它主要在亚太地区流行，尤其是中国。此外，hvKP可以获得碳青霉烯酶基因，导致耐碳青霉烯类高毒力肺炎克雷伯菌（CR-hvKP）的出现，具有高毒力和耐药能力。因此,CR-hvKP对感染控制提出了重大挑战，并对全球公共卫生构成了严重威胁。在本文中,我们提供了流行病学特征的全面总结，毒力因子，以及hvKP菌株中碳青霉烯抗性的潜在机制，旨在为实际预防策略和未来研究提供有价值的见解。
