PDF(Pubmed)
Abstract：
UNASSIGNED: Fluconazole is commonly used to treat and prevent fungal infections caused by Candida and Cryptococcus species. Although there have been reports of fatal arrhythmias induced by fluconazole, such as torsades de pointes, there have been minimal reports of mild, non-fatal arrhythmias associated with it, which may have been overlooked in clinical practice. We encountered a case of frequent premature ventricular contractions induced by fluconazole during the treatment of HIV-related pulmonary cryptococcosis. Herein, we report a case of frequent premature ventricular contractions (PVCs) induced by fluconazole, along with a literature review.
UNASSIGNED: A 47-year-old man diagnosed with human immunodeficiency virus-related pulmonary cryptococcosis experienced an irregular heartbeat during antifungal therapy with fluconazole at 400 mg once daily. A 12-lead electrocardiogram was conducted, which displayed frequent unifocal PVCs originating in the right ventricular outflow tract without QT prolongation. After reducing the dose of fluconazole to 200 mg once daily, the patient\'s symptoms slightly improved, and PVC frequency decreased on a 12-lead ECG; however, PVCs did not disappear. After discontinuing fluconazole, the symptoms improved, and a follow-up 12-lead electrocardiogram showed no PVCs.
UNASSIGNED: We encountered the case of frequent PVCs induced by fluconazole during the treatment of human immunodeficiency virus-related pulmonary cryptococcosis. Furthermore, it was suggested that the PVC frequency was dose-dependent for fluconazole. Careful follow-up for new-onset arrhythmias and ECG evaluations are essential before and after fluconazole administration.
UNASSIGNED: A 47-year-old man diagnosed with human immunodeficiency virus-related pulmonary cryptococcosis experienced an irregular heartbeat during antifungal therapy with fluconazole at 400 mg once daily. A 12-lead electrocardiogram was conducted, which displayed frequent unifocal PVCs originating in the right ventricular outflow tract without QT prolongation. After reducing the dose of fluconazole to 200 mg once daily, the patient\'s symptoms slightly improved, and PVC frequency decreased on a 12-lead ECG; however, PVCs did not disappear. After discontinuing fluconazole, the symptoms improved, and a follow-up 12-lead electrocardiogram showed no PVCs.
UNASSIGNED: We encountered the case of frequent PVCs induced by fluconazole during the treatment of human immunodeficiency virus-related pulmonary cryptococcosis. Furthermore, it was suggested that the PVC frequency was dose-dependent for fluconazole. Careful follow-up for new-onset arrhythmias and ECG evaluations are essential before and after fluconazole administration.
摘要：
■氟康唑通常用于治疗和预防由念珠菌和隐球菌引起的真菌感染。尽管有报道称氟康唑诱发了致命性心律失常,比如尖端扭转，有轻微的报道，与之相关的非致命性心律失常,这在临床实践中可能被忽视了。我们在治疗HIV相关肺隐球菌病时遇到一例氟康唑诱发的室性早搏。在这里，我们报告了一例氟康唑诱发的频发室性早搏（PVC），以及文献综述。
■一名被诊断患有人类免疫缺陷病毒相关肺隐球菌病的47岁男子在接受氟康唑每天一次400mg的抗真菌治疗期间出现不规则心跳。进行了12导联心电图检查，表现出起源于右心室流出道的频繁单中心PVCs，而无QT延长。在将氟康唑的剂量减少到每天200毫克后，患者的症状略有改善，在12导联心电图上，PVC频率降低；然而，PVC没有消失。停用氟康唑后，症状好转,随访12导联心电图显示无PVCs。
■我们在治疗人类免疫缺陷病毒相关肺隐球菌病时遇到了氟康唑诱发的频繁PVCs。此外，提示氟康唑的PVC频率呈剂量依赖性。在氟康唑给药前后，对新发心律失常进行仔细的随访和ECG评估至关重要。
■一名被诊断患有人类免疫缺陷病毒相关肺隐球菌病的47岁男子在接受氟康唑每天一次400mg的抗真菌治疗期间出现不规则心跳。进行了12导联心电图检查，表现出起源于右心室流出道的频繁单中心PVCs，而无QT延长。在将氟康唑的剂量减少到每天200毫克后，患者的症状略有改善，在12导联心电图上，PVC频率降低；然而，PVC没有消失。停用氟康唑后，症状好转,随访12导联心电图显示无PVCs。
■我们在治疗人类免疫缺陷病毒相关肺隐球菌病时遇到了氟康唑诱发的频繁PVCs。此外，提示氟康唑的PVC频率呈剂量依赖性。在氟康唑给药前后，对新发心律失常进行仔细的随访和ECG评估至关重要。
