Abstract：
OBJECTIVE: Homonymous hemianopia caused by cerebrovascular disease may improve over time. This study investigated whether functional neuroimaging can predict the prognosis of hemianopia due to cerebral infarction.
METHODS: We studied 19 patients (10 men and 9 women) with homonymous hemianopia and compared them with 34 healthy subjects (20 men and 14 women). Cerebral glucose metabolism was measured by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), 1 to 6 months after the onset. Bilateral regions of interest (ROIs) were selected from the posterior and, anterior striate cortices, extrastriate cortex, and thalamus. Furthermore, semi-quantitative data on cerebral glucose metabolism were obtained for ROIs and compared with the data obtained for homologous regions in the contralateral hemisphere by calculating the ipsilateral/contralateral (I/C) ratio.
RESULTS: The I/C ratio for the cerebral glucose metabolism in the posterior striate cortex was high (>0.750) in 8 patients, and the central visual field of these patients improved or showed macular sparing. The I/C ratio for cerebral glucose metabolism in the anterior striate cortex was high (>0.830) in 7 patients, and the peripheral visual field of these patients improved. However, no improvement was observed in 9 patients with a low I/C ratio for cerebral glucose metabolism in both the posterior and anterior striate cortices.
CONCLUSIONS: Measurement of cerebral glucose metabolism in the striate cortex is useful for estimating visual field prognosis. Furthermore, FDG-PET is useful in predicting the prognosis of hemianopia.
METHODS: We studied 19 patients (10 men and 9 women) with homonymous hemianopia and compared them with 34 healthy subjects (20 men and 14 women). Cerebral glucose metabolism was measured by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), 1 to 6 months after the onset. Bilateral regions of interest (ROIs) were selected from the posterior and, anterior striate cortices, extrastriate cortex, and thalamus. Furthermore, semi-quantitative data on cerebral glucose metabolism were obtained for ROIs and compared with the data obtained for homologous regions in the contralateral hemisphere by calculating the ipsilateral/contralateral (I/C) ratio.
RESULTS: The I/C ratio for the cerebral glucose metabolism in the posterior striate cortex was high (>0.750) in 8 patients, and the central visual field of these patients improved or showed macular sparing. The I/C ratio for cerebral glucose metabolism in the anterior striate cortex was high (>0.830) in 7 patients, and the peripheral visual field of these patients improved. However, no improvement was observed in 9 patients with a low I/C ratio for cerebral glucose metabolism in both the posterior and anterior striate cortices.
CONCLUSIONS: Measurement of cerebral glucose metabolism in the striate cortex is useful for estimating visual field prognosis. Furthermore, FDG-PET is useful in predicting the prognosis of hemianopia.
摘要：
目的：由脑血管疾病引起的同型偏盲可能会随着时间的推移而改善。这项研究调查了功能神经影像学是否可以预测由于脑梗死引起的偏盲的预后。
方法：我们研究了19名患者（10名男性和9名女性）的同义偏盲，并将其与34名健康受试者（20名男性和14名女性）进行了比较。通过18F-氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）测量脑葡萄糖代谢，发病后1至6个月。从后部和后部选择双侧感兴趣区域(ROI)，前条纹皮质，皮质外,还有丘脑.此外，通过计算同侧/对侧（I/C）比，获得了ROI的脑葡萄糖代谢半定量数据，并将其与对侧半球同源区域的数据进行了比较。
结果：8例患者的后纹状体皮质中脑葡萄糖代谢的I/C比值较高（>0.750），这些患者的中央视野改善或显示黄斑保留。7例患者前纹状体皮质脑葡萄糖代谢I/C比值较高(>0.830),这些患者的周边视野得到改善。然而,在9例I/C比值较低的患者中,前后条纹皮质的脑葡萄糖代谢均无改善.
结论：测量纹状体皮质中的脑葡萄糖代谢对于估计视野预后是有用的。此外，FDG-PET可用于预测偏盲的预后。
方法：我们研究了19名患者（10名男性和9名女性）的同义偏盲，并将其与34名健康受试者（20名男性和14名女性）进行了比较。通过18F-氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）测量脑葡萄糖代谢，发病后1至6个月。从后部和后部选择双侧感兴趣区域(ROI)，前条纹皮质，皮质外,还有丘脑.此外，通过计算同侧/对侧（I/C）比，获得了ROI的脑葡萄糖代谢半定量数据，并将其与对侧半球同源区域的数据进行了比较。
结果：8例患者的后纹状体皮质中脑葡萄糖代谢的I/C比值较高（>0.750），这些患者的中央视野改善或显示黄斑保留。7例患者前纹状体皮质脑葡萄糖代谢I/C比值较高(>0.830),这些患者的周边视野得到改善。然而,在9例I/C比值较低的患者中,前后条纹皮质的脑葡萄糖代谢均无改善.
结论：测量纹状体皮质中的脑葡萄糖代谢对于估计视野预后是有用的。此外，FDG-PET可用于预测偏盲的预后。
