Abstract：
BACKGROUND: The use of appropriate animal models for cancer studies is a major challenge, particularly for investigators who lack the resources to maintain and use xenograft animals or genetically engineered mouse models (GEMM). In addition, several countries intending to incorporate these models must conduct importation procedures, posing an additional challenge.
OBJECTIVE: This review aimed to explore the use of cell-derived allograft or syngeneic models under limited resources. The results can be used by investigators, specifically from low-middle-income countries, to contribute to lung cancer eradication.
METHODS: A literature search was carried out on various databases, including PubMed, Web of Science, and Scopus. In addition, the publication year of the selected articles was set between 2013 and 2023 with different search components (SC), namely lung cancer (SC1), animal models (SC2), and preclinical studies (SC3).
RESULTS: This systematic review focused on selecting animals, cells, and methods that could be applied to generating allograft-type lung cancer animal models from 101 included articles.
CONCLUSIONS: Based on the results, the use of cell-derived allograft models in cancer studies is feasible and relevant, and it provides valuable insights regarding the conditions with limited resources.
OBJECTIVE: This review aimed to explore the use of cell-derived allograft or syngeneic models under limited resources. The results can be used by investigators, specifically from low-middle-income countries, to contribute to lung cancer eradication.
METHODS: A literature search was carried out on various databases, including PubMed, Web of Science, and Scopus. In addition, the publication year of the selected articles was set between 2013 and 2023 with different search components (SC), namely lung cancer (SC1), animal models (SC2), and preclinical studies (SC3).
RESULTS: This systematic review focused on selecting animals, cells, and methods that could be applied to generating allograft-type lung cancer animal models from 101 included articles.
CONCLUSIONS: Based on the results, the use of cell-derived allograft models in cancer studies is feasible and relevant, and it provides valuable insights regarding the conditions with limited resources.
摘要：
背景：使用适当的动物模型进行癌症研究是一项重大挑战，特别是对于缺乏维持和使用异种移植动物或基因工程小鼠模型（GEMM）资源的研究人员。此外,几个打算纳入这些模式的国家必须进行进口程序，带来了额外的挑战。
目的：这篇综述旨在探索在有限资源下使用细胞来源的同种异体移植或同基因模型。结果可供调查人员使用，特别是来自中低收入国家，有助于肺癌根除。
方法：在各种数据库上进行了文献检索，包括PubMed,WebofScience,还有Scopus.此外,选定文章的出版年份设置在2013年至2023年之间，具有不同的搜索组件(SC)，即肺癌（SC1），动物模型（SC2），和临床前研究（SC3）。
结果：本系统综述集中于选择动物，细胞,和可用于产生同种异体移植型肺癌动物模型的方法来自101篇文章。
结论：根据结果，在癌症研究中使用细胞来源的同种异体移植模型是可行和相关的，它提供了有关资源有限的条件的宝贵见解。
目的：这篇综述旨在探索在有限资源下使用细胞来源的同种异体移植或同基因模型。结果可供调查人员使用，特别是来自中低收入国家，有助于肺癌根除。
方法：在各种数据库上进行了文献检索，包括PubMed,WebofScience,还有Scopus.此外,选定文章的出版年份设置在2013年至2023年之间，具有不同的搜索组件(SC)，即肺癌（SC1），动物模型（SC2），和临床前研究（SC3）。
结果：本系统综述集中于选择动物，细胞,和可用于产生同种异体移植型肺癌动物模型的方法来自101篇文章。
结论：根据结果，在癌症研究中使用细胞来源的同种异体移植模型是可行和相关的，它提供了有关资源有限的条件的宝贵见解。
