PGE2 通过破坏 IL - 2 信号传导和线粒体功能来抑制 TIL 扩增。
Mesh : Animals Humans Mice CD8-Positive T-Lymphocytes / cytology immunology metabolism Cell Proliferation Dinoprostone / metabolism Down-Regulation Ferroptosis Interleukin Receptor Common gamma Subunit / biosynthesis deficiency metabolism Interleukin-2 / antagonists & inhibitors immunology metabolism Interleukin-2 Receptor beta Subunit / metabolism Lymphocytes, Tumor-Infiltrating / cytology immunology metabolism Mitochondria / metabolism Oxidative Stress Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Receptors, Prostaglandin E, EP2 Subtype / metabolism antagonists & inhibitors Receptors, Prostaglandin E, EP4 Subtype / metabolism antagonists & inhibitors Signal Transduction TOR Serine-Threonine Kinases / metabolism Tumor Microenvironment / immunology
来 源:
DOI:10.1038/s41586-024-07352-w
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