Abstract：
OBJECTIVE: Salivary gland cancers (SGC) are rare neoplasms which comprise 1-5 % of all head and neck cancers. SGCs can be managed by resection, radiosurgery, chemotherapy, or a combination of these. Our team appraised the quality of clinical practice guidelines (CPGs) for SGC treatment and management using the Appraisal of Guidelines for Research and Evaluation (AGREE-II) instrument.
METHODS: PubMed, Scopus, & EMBASE were reviewed for CPGs regarding SGC management from database inception to January 1st, 2023.
METHODS: The AGREE-II instrument was used by 4 reviewers to independently evaluate guidelines. Domain scores were generated with a satisfactory threshold being >60 % - a \"high\" quality CPG required >4 satisfactory domains. Intraclass correlation coefficients (ICCs) were used, via R 4.2.1., to determine inter-reviewer variability.
RESULTS: Literature review identified 645 articles, with six being included after applying inclusion and exclusion criteria. Of the six included articles, one CPG was \"high\" quality and 5 were \"low\" quality. The domains with the highest scores were \"Editorial Independence\" (72.57 ± 36.60) and \"Clarity and Presentation\" (63.19 ± 26.08), while the lowest were \"Rigor of Development\" (34.03 ± 30.63) and \"Applicability\" (30.21 ± 30.46). ICC scores for each domain ranged from 0.937 to 0.983, indicating a high level of inter-rater agreement.
CONCLUSIONS: This study found that most CPGs for the treatment and management of SGC were of \"low\" quality, with only one guideline being considered \"high\" quality based on the standard set by the AGREE-II instrument. These findings indicate that there is a high level of variability and little standardization when it comes to the quality of CPGs.
METHODS: PubMed, Scopus, & EMBASE were reviewed for CPGs regarding SGC management from database inception to January 1st, 2023.
METHODS: The AGREE-II instrument was used by 4 reviewers to independently evaluate guidelines. Domain scores were generated with a satisfactory threshold being >60 % - a \"high\" quality CPG required >4 satisfactory domains. Intraclass correlation coefficients (ICCs) were used, via R 4.2.1., to determine inter-reviewer variability.
RESULTS: Literature review identified 645 articles, with six being included after applying inclusion and exclusion criteria. Of the six included articles, one CPG was \"high\" quality and 5 were \"low\" quality. The domains with the highest scores were \"Editorial Independence\" (72.57 ± 36.60) and \"Clarity and Presentation\" (63.19 ± 26.08), while the lowest were \"Rigor of Development\" (34.03 ± 30.63) and \"Applicability\" (30.21 ± 30.46). ICC scores for each domain ranged from 0.937 to 0.983, indicating a high level of inter-rater agreement.
CONCLUSIONS: This study found that most CPGs for the treatment and management of SGC were of \"low\" quality, with only one guideline being considered \"high\" quality based on the standard set by the AGREE-II instrument. These findings indicate that there is a high level of variability and little standardization when it comes to the quality of CPGs.
摘要：
目的：唾液腺癌（SGC）是罕见的肿瘤，占所有头颈部癌症的1-5％。SGC可以通过切除来管理，放射外科,化疗,或者这些的组合。我们的团队使用研究和评估指南（AGREE-II）工具评估了SGC治疗和管理的临床实践指南（CPG）的质量。
方法：PubMed，Scopus,&EMBASE从数据库开始到1月1日，对有关SGC管理的CPG进行了审查，2023年。
方法：4名评审员使用AGREE-II工具独立评估指南。生成的域分数的满意阈值>60%-要求“高质量”CPG>4个满意域。使用了类内相关系数(ICC)，通过R4.2.1。,以确定审阅者之间的可变性。
结果：文献综述确定了645篇文章，在应用纳入和排除标准后纳入6项。在六篇文章中，一个CPG是“高”质量，5个是“低”质量。得分最高的领域是“编辑独立性”（72.57±36.60）和“清晰度和呈现”（63.19±26.08），而最低的是“发展的严谨性”（34.03±30.63）和“适用性”（30.21±30.46）。每个领域的ICC得分范围为0.937至0.983，表明评分者之间的一致性很高。
结论：这项研究发现，用于治疗和管理SGC的大多数CPGs质量低，根据AGREE-II仪器设定的标准，只有一个准则被认为是“高质量”。这些发现表明，当涉及到CPG的质量时，存在高度的变异性和很少的标准化。
方法：PubMed，Scopus,&EMBASE从数据库开始到1月1日，对有关SGC管理的CPG进行了审查，2023年。
方法：4名评审员使用AGREE-II工具独立评估指南。生成的域分数的满意阈值>60%-要求“高质量”CPG>4个满意域。使用了类内相关系数(ICC)，通过R4.2.1。,以确定审阅者之间的可变性。
结果：文献综述确定了645篇文章，在应用纳入和排除标准后纳入6项。在六篇文章中，一个CPG是“高”质量，5个是“低”质量。得分最高的领域是“编辑独立性”（72.57±36.60）和“清晰度和呈现”（63.19±26.08），而最低的是“发展的严谨性”（34.03±30.63）和“适用性”（30.21±30.46）。每个领域的ICC得分范围为0.937至0.983，表明评分者之间的一致性很高。
结论：这项研究发现，用于治疗和管理SGC的大多数CPGs质量低，根据AGREE-II仪器设定的标准，只有一个准则被认为是“高质量”。这些发现表明，当涉及到CPG的质量时，存在高度的变异性和很少的标准化。
