Abstract：
OBJECTIVE: To analyze the available evidence and assess the effect of different implant coatings on healing outcomes.
METHODS: Using the PICOS strategy, a structured question was formed. A protocol was agreed upon and registered with PROSPERO (no. CRD42022321926). The MEDLINE, Embase, Cochrane Database of Systematic Reviews, Scopus, Web of Science, Pubmed, and ScienceDirect databases were searched using a structured strategy. Study selection was independently carried out in duplicate, first by title and abstract, then by full-text assessment. Quality and risk of bias were independently assessed in duplicate using AMSTAR 2 and ROBIS. Data extraction was independently undertaken in duplicate using a predefined extraction form.
RESULTS: The search yielded 11 systematic reviews for inclusion. The most commonly assessed coatings were based on calcium phosphate-including hydroxyapatite (HA), brushite, and bioabsorbable nano-HA-followed by bisphosphonate, then bioactive glass coatings. Included reviews most frequently assessed marginal bone loss (MBL), bone-to-implant contact (BIC), and survival/success rates. There was considerable heterogeneity and small sample sizes. The quality assessment suggested low confidence in the reviews and high risk of bias.
CONCLUSIONS: The included reviews provide weak evidence that implant coatings improve osseointegration and reduce MBL following implant placement. There was weak evidence for progressive complications for calcium phosphate coatings. Further research and long-term multicenter controlled clinical trials with improved standardization and control of bias are required to better understand the effects of coating implants.
METHODS: Using the PICOS strategy, a structured question was formed. A protocol was agreed upon and registered with PROSPERO (no. CRD42022321926). The MEDLINE, Embase, Cochrane Database of Systematic Reviews, Scopus, Web of Science, Pubmed, and ScienceDirect databases were searched using a structured strategy. Study selection was independently carried out in duplicate, first by title and abstract, then by full-text assessment. Quality and risk of bias were independently assessed in duplicate using AMSTAR 2 and ROBIS. Data extraction was independently undertaken in duplicate using a predefined extraction form.
RESULTS: The search yielded 11 systematic reviews for inclusion. The most commonly assessed coatings were based on calcium phosphate-including hydroxyapatite (HA), brushite, and bioabsorbable nano-HA-followed by bisphosphonate, then bioactive glass coatings. Included reviews most frequently assessed marginal bone loss (MBL), bone-to-implant contact (BIC), and survival/success rates. There was considerable heterogeneity and small sample sizes. The quality assessment suggested low confidence in the reviews and high risk of bias.
CONCLUSIONS: The included reviews provide weak evidence that implant coatings improve osseointegration and reduce MBL following implant placement. There was weak evidence for progressive complications for calcium phosphate coatings. Further research and long-term multicenter controlled clinical trials with improved standardization and control of bias are required to better understand the effects of coating implants.
摘要：
目的：分析现有证据并评估不同种植体涂层对愈合结果的影响。
方法：使用PICOS策略，形成了一个结构化的问题。协议已商定并在PROSPERO注册（编号：CRD42022321926）。MEDLINE,Embase,Cochrane系统评价数据库，Scopus,WebofScience,Pubmed,和ScienceDirect数据库使用结构化策略进行搜索。研究选择独立进行，一式两份，首先是标题和摘要，然后通过全文评估。使用AMSTAR2和ROBIS独立评估质量和偏倚风险。使用预定义的提取形式以一式两份独立地进行数据提取。
结果：搜索产生了11个系统评价纳入。最常用的评估涂层是基于磷酸钙-包括羟基磷灰石（HA），brushite,和生物可吸收的纳米HA-其次是双膦酸盐，然后是生物活性玻璃涂层。纳入的评论最常评估的边缘骨丢失（MBL），骨与植入物接触（BIC），和存活率/成功率。存在相当大的异质性和小样本量。质量评估表明对评论的置信度低，偏见风险高。
结论：纳入的综述提供了微弱的证据，表明植入物涂层可改善骨整合并降低植入物放置后的MBL。磷酸钙涂层进行性并发症的证据很少。为了更好地了解涂层植入物的效果，需要进一步的研究和具有改进的标准化和偏见控制的长期多中心对照临床试验。
方法：使用PICOS策略，形成了一个结构化的问题。协议已商定并在PROSPERO注册（编号：CRD42022321926）。MEDLINE,Embase,Cochrane系统评价数据库，Scopus,WebofScience,Pubmed,和ScienceDirect数据库使用结构化策略进行搜索。研究选择独立进行，一式两份，首先是标题和摘要，然后通过全文评估。使用AMSTAR2和ROBIS独立评估质量和偏倚风险。使用预定义的提取形式以一式两份独立地进行数据提取。
结果：搜索产生了11个系统评价纳入。最常用的评估涂层是基于磷酸钙-包括羟基磷灰石（HA），brushite,和生物可吸收的纳米HA-其次是双膦酸盐，然后是生物活性玻璃涂层。纳入的评论最常评估的边缘骨丢失（MBL），骨与植入物接触（BIC），和存活率/成功率。存在相当大的异质性和小样本量。质量评估表明对评论的置信度低，偏见风险高。
结论：纳入的综述提供了微弱的证据，表明植入物涂层可改善骨整合并降低植入物放置后的MBL。磷酸钙涂层进行性并发症的证据很少。为了更好地了解涂层植入物的效果，需要进一步的研究和具有改进的标准化和偏见控制的长期多中心对照临床试验。
