PDF(Pubmed)
Abstract：
Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz, has demonstrated a promising potential in improving diabetic nephropathy (DN). However, the specific active constituent(s) responsible for its therapeutic effects and the underlying pharmacological mechanisms remain unclear. In this study, we aimed to investigate the impact of scutellarin, a constituent of breviscapine, on streptozotocin-induced diabetic nephropathy and elucidate its pharmacological mechanism(s). Our findings demonstrate that scutellarin effectively ameliorates various features of DN in vivo, including proteinuria, glomerular expansion, mesangial matrix accumulation, renal fibrosis, and podocyte injury. Mechanistically, scutellarin appears to exert its beneficial effects through modulation of the transforming growth factor-β1 (TGF-β1) signaling pathway, as well as its interaction with the extracellular signal-regulated kinase (Erk) and Wnt/β-catenin pathways.
摘要：
灯盏花素,一种天然类黄酮混合物，源自传统中草药灯盏花（Vant。)Hand-Mazz,在改善糖尿病肾病（DN）方面表现出了有希望的潜力。然而,负责其治疗效果的具体活性成分和潜在的药理机制仍不清楚.在这项研究中,我们的目的是调查scutellarin的影响，灯盏花素的成分，关于链脲佐菌素诱导的糖尿病肾病，并阐明其药理机制。我们的发现表明，灯盏乙素有效地改善了体内DN的各种特征，包括蛋白尿,肾小球扩张，系膜基质积累，肾纤维化,足细胞损伤.机械上,灯盏乙素似乎通过调节转化生长因子-β1（TGF-β1）信号通路发挥其有益作用，以及它与细胞外信号调节激酶（Erk）和Wnt/β-catenin通路的相互作用。
